Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B
The American journal of clinical nutrition · 1,534 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Hartford Foundation for Public Giving
- Organización sin fines de lucro
- Stiftung zur Förderung der Ernährungsforschung in der Schweiz
Según 2 financiadores declarados.
Publicación
- Publicado
- 2006-07-01 · Am J Clin Nutr · vol. 84 · número 1 · págs. 18–28
- Editorial
- Elsevier BV
- Citado
- 2,419 citas · más que el 100% de estudios similares · 90.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 173 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Nutrition and Health Studies
- Palabras clave
- 25-hydroxyvitamin D, vitamin D supplementation, vitamin D intake recommendations, bone mineral density, lower limb function, dental health, falls and fractures, colorectal cancer, older adults, vitamin D dose
- MeSH
- humans, colorectal neoplasms, osteoporosis, periodontal diseases, vitamin d, risk factors, age factors, bone density, dose-response relationship, drug, nutrition policy, bone density conservation agents
5 autores
- Heike Annette Bischoff-Ferrari🇺🇸🇨🇭 · autor de correspondenciaBoston University; Tufts University; Brigham and Women's Hospital; Harvard University; University of Zurich; University Hospital Zurich; Jean Mayer Human Nutrition Research Center on Aging
- Edward L. Giovannucci🇺🇸🇨🇭Boston University; Tufts University; Brigham and Women's Hospital; Harvard University; University of Zurich; University Hospital Zurich; Jean Mayer Human Nutrition Research Center on Aging
- Walter Churchill Willett🇺🇸🇨🇭Boston University; Tufts University; Brigham and Women's Hospital; Harvard University; University of Zurich; University Hospital Zurich; Jean Mayer Human Nutrition Research Center on Aging
- Thomas Dietrich🇺🇸🇨🇭Boston University; Tufts University; Brigham and Women's Hospital; Harvard University; University of Zurich; University Hospital Zurich; Jean Mayer Human Nutrition Research Center on Aging
- Bess Dawson‐Hughes🇺🇸🇨🇭Boston University; Tufts University; Brigham and Women's Hospital; Harvard University; University of Zurich; University Hospital Zurich; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Recent evidence suggests that vitamin D intakes above current recommendations may be associated with better health outcomes. However, optimal serum concentrations of 25-hydroxyvitamin D [25(OH)D] have not been defined. This review summarizes evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density (BMD), lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer. For all endpoints, the most advantageous serum concentrations of 25(OH)D begin at 75 nmol/L (30 ng/mL), and the best are between 90 and 100 nmol/L (36-40 ng/mL). In most persons, these concentrations could not be reached with the currently recommended intakes of 200 and 600 IU vitamin D/d for younger and older adults, respectively. A comparison of vitamin D intakes with achieved serum concentrations of 25(OH)D for the purpose of estimating optimal intakes led us to suggest that, for bone health in younger adults and all studied outcomes in older adults, an increase in the currently recommended intake of vitamin D is warranted. An intake for all adults of > or =1000 IU (25 microg) [DOSAGE ERROR CORRECTED] vitamin D (cholecalciferol)/d is needed to bring vitamin D concentrations in no less than 50% of the population up to 75 nmol/L. The implications of higher doses for the entire adult population should be addressed in future studies.
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