Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio
Goyens PL, Spilker ME, Zock PL, Katan MB, Mensink RP
The American journal of clinical nutrition · 240 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Biomedical Imaging and Bioengineering
- Gobierno
- NIBIB NIH HHS
- Subvenciones
- National Institute of Biomedical Imaging and Bioengineering (P41EB001975)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2006-07-01 · Am J Clin Nutr · vol. 84 · número 1 · págs. 44–53
- Editorial
- Elsevier BV
- Citado
- 391 citas · más que el 99% de estudios similares · 16.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and biosynthesis · Aquaculture Nutrition and Growth
- Palabras clave
- alpha-linolenic acid, linoleic acid, dietary fatty acid ratio, omega-3 fatty acid metabolism, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, plasma phospholipids, dietary intervention
- MeSH
- humans, carbon isotopes, alpha-linolenic acid, fatty acids, unsaturated, linoleic acid, phospholipids, breath tests, double-blind method, oxidation-reduction, dose-response relationship, drug, middle aged, female, male
5 autores
- Petra L.L. Goyens🇩🇪🇳🇱 · autor de correspondenciaTUM Klinikum; Maastricht University; Technical University of Munich; Wageningen University & Research
- Mary E. Spilker🇩🇪🇳🇱TUM Klinikum; Maastricht University; Technical University of Munich; Wageningen University & Research
- Peter L. Zock🇩🇪🇳🇱TUM Klinikum; Maastricht University; Technical University of Munich; Wageningen University & Research
- Mira Katan🇩🇪🇳🇱TUM Klinikum; Maastricht University; Technical University of Munich; Wageningen University & Research
- Ronald P. Mensink🇩🇪🇳🇱TUM Klinikum; Maastricht University; Technical University of Munich; Wageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Human in vivo data on dietary determinants of alpha-linolenic acid (ALA; 18:3n-3) metabolism are scarce.
Objective
We examined whether intakes of ALA or linoleic acid (LA; 18:2n-6) or their ratio influences ALA metabolism.
Design
During 4 wk, 29 subjects received a control diet (7% of energy from LA, 0.4% of energy from ALA, ALA-to-LA ratio = 1:19). For the next 6 wk, a control diet, a low-LA diet (3% of energy from LA, 0.4% of energy from ALA, ratio = 1:7), or a high-ALA diet (7% of energy from LA, 1.1% of energy from ALA, ratio = 1:7) was consumed. Ten days before the end of each dietary period, [U-13C]ALA was administered orally for 9 d. ALA oxidation was determined from breath. Conversion was estimated by using compartmental modeling of [13C]- and [12C]n-3 fatty acid concentrations in fasting plasma phospholipids.
Results
Compared with the control group, ALA incorporation into phospholipids increased by 3.6% in the low-LA group (P = 0.012) and decreased by 8.0% in the high-ALA group (P < 0.001). In absolute amounts, it increased by 34.3 mg (P = 0.020) in the low-LA group but hardly changed in the high-ALA group. Nearly all ALA from the plasma phospholipid pool was converted into eicosapentaenoic acid. Conversion of eicosapentaenoic acid into docosapentaenoic acid and docosahexaenoic acid hardly changed in the 3 groups and was <0.1% of dietary ALA. In absolute amounts, it was unchanged in the low-LA group, but increased from 0.7 to 1.9 mg (P = 0.001) in the high-ALA group. ALA oxidation was unchanged by the dietary interventions.
Conclusion
The amounts of ALA and LA in the diet, but not their ratio, determine ALA conversion.
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