Why do omega-3 fatty acids lower serum triglycerides?
Harris WS, Bulchandani D
Current opinion in lipidology · 260 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-07-10 · Curr Opin Lipidol · vol. 17 · número 4 · págs. 387–393
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 398 citas · más que el 99% de estudios similares · 15.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and biosynthesis · Lipid metabolism and disorders
- Palabras clave
- omega-3 fatty acids, fish oil, serum triglycerides, triglyceride synthesis, lipogenesis, hepatic fatty acid synthesis, fatty acid beta-oxidation, very low density lipoprotein secretion, diacylglycerol acyltransferase, phosphatidic acid phosphohydrolase, phospholipid synthesis, rat model
- MeSH
- animals, humans, rats, fatty acids, omega-3, triglycerides, gene expression regulation
2 autores
- William Stephen Harris🇺🇸 · autor de correspondenciaSaint Luke's Health System; University of Missouri–Kansas City
- Deepti G. Bulchandani🇺🇸University of Missouri–Kansas City
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose of review
Fish oils rich in n-3 fatty acids reduce serum triglyceride levels. This well known effect has been shown to be caused by decreased very low-density lipoprotein triglyceride secretion rates in kinetic studies in humans. Animal studies have explored the biochemical mechanisms underlying this effect. Triglyceride synthesis could be reduced by n-3 fatty acids in three general ways: reduced substrate (i.e. fatty acids) availability, which could be secondary to increase in beta-oxidation, decreased free fatty acids delivery to the liver, decreased hepatic fatty acids synthesis; increased phospholipid synthesis; or decreased activity of triglyceride-synthesizing enzymes (diacylgylcerol acyltranferase or phosphatidic acid phosphohydrolase).
Recent findings
Rarely were experimental conditions used in rat studies physiologically relevant to the human situation in which 1.2% energy as n-3 fatty acids lowers serum triglyceride levels. Nevertheless, the most consistent effect of n-3 fatty acids feeding in rats is to decrease lipogenesis. Increased beta-oxidation was frequently, but not consistently, reported with similar numbers of studies reporting increased mitochondrial compared with peroxisomal oxidation. Inhibition of triglyceride-synthesizing enzymes was only occasionally noted.
Summary
As the vast majority of studies fed unphysiologically high doses of n-3 fatty acids, these findings in rats must be considered tentative, and the mechanism by which n-3 fatty acids reduce triglyceride levels in humans remains speculative.
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