Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock
Pontes-Arruda A, Aragão AM, Albuquerque JD
Critical care medicine · 246 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-07-18 · Crit Care Med · vol. 34 · número 9 · págs. 2325–2333
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 425 citas · más que el 100% de estudios similares · 24.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Sepsis Diagnosis and Treatment · Nosocomial Infections in ICU
- Palabras clave
- enteral nutrition, eicosapentaenoic acid, gamma-linolenic acid, omega-3 fatty acids, antioxidants, vitamin supplementation, sepsis, septic shock, mechanical ventilation, 28-day mortality, ventilator-free days, ICU-free days, organ dysfunction, critically ill patients
- MeSH
- humans, sepsis, shock, septic, multiple organ failure, ascorbic acid, vitamin e, eicosapentaenoic acid, gamma-linolenic acid, antioxidants, pulmonary gas exchange, respiration, artificial, enteral nutrition, length of stay, prospective studies, double-blind method, aged, middle aged, intensive care units, brazil, female, male, respiratory distress syndrome
3 autores
- Alessandro Pontes‐Arruda🇧🇷Latin American Sepsis Institute; Hospital Fernandes Távora
- Afra Maria Albuquerque Aragão🇧🇷Latin American Sepsis Institute; Hospital Fernandes Távora
- Juliana Deusdará Albuquerque🇧🇷Latin American Sepsis Institute; Hospital Fernandes Távora
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Enteral diets enriched with eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and antioxidants have previously been shown to improve outcomes in patients with acute respiratory distress syndrome. Several studies using animal models of sepsis demonstrate that enteral nutrition enriched with omega-3 fatty acids reduces mortality rate. This study investigated whether an enteral diet enriched with EPA, GLA, and antioxidant vitamins can improve outcomes and reduce 28-day all-cause mortality in patients with severe sepsis or septic shock requiring mechanical ventilation.
Design
Prospective, double-blind, placebo-controlled, randomized trial.
Setting
Three different intensive care units of a tertiary hospital in Brazil.
Patients
The study enrolled 165 patients.
Interventions
Patients were randomized to be continuously tube-fed with either a diet enriched with EPA, GLA, and elevated antioxidants or an isonitrogenous and isocaloric control diet, delivered at a constant rate to achieve a minimum of 75% of basal energy expenditure x 1.3 during a minimum of 4 days.
Measurements and main results
Patients were monitored for 28 days. Patients who were fed with the study diet experienced a significant reduction in mortality rate compared with patients fed with the control diet, the absolute mortality reduction amounting to 19.4% (p = .037). The group who received the study diet also experienced significant improvements in oxygenation status, more ventilator-free days (13.4 +/- 1.2 vs. 5.8 +/- 1.0, p < .001), more intensive care unit (ICU)-free days (10.8 +/- 1.1 vs. 4.6 +/- 0.9, p < .001), and a lesser development of new organ dysfunctions (p < .001).
Conclusions
In patients with severe sepsis or septic shock and requiring mechanical ventilation and tolerating enteral nutrition, a diet enriched with EPA, GLA, and elevated antioxidants contributed to better ICU and hospital outcomes and was associated with lower mortality rates.
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