Processed meat consumption and stomach cancer risk: a meta-analysis
Larsson SC, Orsini N, Wolk A
Journal of the National Cancer Institute · 98 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-08-02 · J Natl Cancer Inst · vol. 98 · número 15 · págs. 1078–1087
- Editorial
- Oxford University Press
- Citado
- 160 citas · más que el 65% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 64 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Meat and Animal Product Quality · Esophageal Cancer Research and Treatment
- Palabras clave
- processed meat consumption, gastric cancer, cancer risk, bacon, dietary factors, dose-response relationship, confounding
- MeSH
- humans, stomach neoplasms, risk assessment, risk factors, case-control studies, cohort studies, meat products, adult, aged, middle aged, female, male
3 autores
- Susanna C. Larsson🇸🇪Karolinska Institutet
- Nicola Orsini🇸🇪Karolinska Institutet
- Alicja Wolk🇸🇪Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The relationship between processed meat consumption and the risk of stomach cancer is controversial. We conducted a meta-analysis to summarize available evidence from cohort and case-control studies on this issue.
Methods
We searched Medline for studies of processed meat consumption and stomach cancer published from January 1966 through March 2006. Random-effects models were used to pool the relative risks from individual studies. All statistical tests were two-sided.
Results
Six prospective cohort studies (involving 2209 stomach cancer patients) and nine case-control studies (2495 case patients) were eligible for inclusion in the dose-response meta-analysis of processed meat consumption. The estimated summary relative risks of stomach cancer for an increase in processed meat consumption of 30 g/day, approximately half of an average serving, were 1.15 (95% confidence interval [CI] = 1.04 to 1.27) for the cohort studies and 1.38 (95% CI = 1.19 to 1.60) for the case-control studies. There was no statistically significant heterogeneity among the cohort studies (P = .42) or among the case-control studies (P = .19). In three cohort and four case-control studies that examined the association between bacon consumption and stomach cancer, the summary relative risk was 1.37 (95% CI = 1.17 to 1.61) for the highest versus lowest intake categories of bacon, without heterogeneity among these studies (P = .66).
Conclusion
Increased consumption of processed meat is associated with an increased risk of stomach cancer. However, the possibility that the association may be confounded or modified by other factors cannot be ruled out.
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