A pilot study on the effects of almond consumption on DNA damage and oxidative stress in smokers
Jia X, Li N, Zhang W, Zhang X, Lapsley K, Huang G, Blumberg J, Ma G, Chen J
Nutrition and cancer · 44 citas
Etiquetas de revisión
Alimentación controladaFinanciación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-07-01 · Nutr Cancer · vol. 54 · número 2 · págs. 179–183
- Editorial
- Routledge
- Citado
- 64 citas · más que el 83% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 19 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Phytochemicals and Antioxidant Activities
- Palabras clave
- almond consumption, DNA damage, oxidative stress, cigarette smokers, 8-hydroxy-2'-deoxyguanosine, single-strand breaks, malondialdehyde, superoxide dismutase, glutathione peroxidase, dietary antioxidants
- MeSH
- lymphocytes, humans, prunus, dna damage, malondialdehyde, glutathione peroxidase, superoxide dismutase, deoxyguanosine, enzyme-linked immunosorbent assay, comet assay, pilot projects, smoking, oxidative stress, dose-response relationship, drug, adolescent, adult, male, biomarkers, 8-hydroxy-2'-deoxyguanosine
9 autores
- Xudong Jia🇨🇳Chinese Center For Disease Control and Prevention
- Ning Li
- Wenzhong Zhang
- Xiaopeng Zhang
- Karen Lapsley
- Guangwei Huang
- Jeffrey B. Blumberg
- Guansheng Ma
- Junshi Chen
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effects of almond consumption on DNA damage and oxidative stress among cigarette smokers were studied. Thirty healthy adult male regular smokers were randomly divided into three groups, 10 subjects per group. Group A (control group) did not receive any almonds. Subjects in Groups B and C received 3 oz and 6 oz (84 g and 168 g) of almonds each day respectively for 4 wk. Two known biomarkers for DNA damage, urinary 8-hydroxy-2'-deoxyguanosine (8-OH-dG) and single strand DNA breaks of peripheral blood lymphocytes, were measured by enzyme-linked immunosorbent assay and comet assay, respectively. In addition, plasma malondialdehyde (MDA) level, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities were measured as biomarkers for oxidative stress. The results showed lower levels of urinary 8-OH-dG and single strand DNA breaks in the two almond-treated groups as compared with the control group. Furthermore, MDA levels in the almond-treated groups were lower than the controls. However, no significant effects of almonds on SOD and GSH-Px activities were found. In conclusion, results from this pilot study indicate that almond consumption has preventive effects on oxidative stress and DNA damage caused by smoking. A larger, randomized, placebo-controlled clinical trial on almonds will be initiated in the near future.
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