Metaanálisis2006Financiación no declarada
The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis
Uitterlinden AG, Ralston SH, Brandi ML, Carey AH, Grinberg D, Langdahl BL, Lips P, Lorenc R, Obermayer-Pietsch B, Reeve J, Reid DM, Amedei A, Bassiti A, Bustamante M, Husted LB, Diez-Perez A, Dobnig H, Dunning AM, Enjuanes A, Fahrleitner-Pammer A, Fang Y, Karczmarewicz E, Kruk M, van Leeuwen JP, Mavilia C, van Meurs JB, Mangion J, McGuigan FE, Pols HA, Renner W, Rivadeneira F, van Schoor NM, Scollen S, Sherlock RE, Ioannidis JP, APOSS Investigators, EPOS Investigators, EPOLOS Investigators, FAMOS Investigators, LASA Investigators, Rotterdam Study Investigators, GENOMOS Study
Annals of internal medicine · 155 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-08-15 · Ann Intern Med · vol. 145 · número 4 · págs. 255–264
- Editorial
- American College of Physicians
- Citado
- 252 citas · más que el 100% de estudios similares · 27.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Bone health and osteoporosis research · Vitamin D Research Studies · Genetic Associations and Epidemiology
- Palabras clave
- vitamin D receptor, VDR polymorphisms, osteoporosis, bone mineral density, fracture, vertebral fractures, FokI polymorphism, BsmI polymorphism, ApaI polymorphism, TaqI polymorphism, genetic susceptibility, women
- MeSH
- humans, osteoporosis, deoxyribonucleases, type ii site-specific, homeodomain proteins, receptors, calcitriol, prospective studies, bone density, genotype, haplotypes, polymorphism, genetic, adult, aged, middle aged, female, male, fractures, bone, promoter regions, genetic, cdx2 transcription factor
42 autores
- André Gerardus Uitterlinden🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Stuart H. Ralston🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Maria Luisa Brandi🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Alisoun H. Carey🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Oxagen (United Kingdom); Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Daniel Grinberg🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Bente Lomholt Langdahl🇪🇸🇬🇷🇬🇧🇩🇰🇳🇱🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; Aarhus University; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Paul T.A.M. Lips🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Vrije Universiteit Amsterdam; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Roman S Lorenc🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇵🇱🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Children's Memorial Health Institute; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Barbara Maria Obermayer-Pietsch🇪🇸🇬🇷🇬🇧🇦🇹🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; Medical University of Graz; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- JONATHAN REEVE🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- David M. Reid🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Antonietta Amedei🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Amelia Bassiti🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Mariona Bustamante🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Lise Bjerre Husted🇪🇸🇬🇷🇬🇧🇩🇰🇳🇱🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; Aarhus University; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Adolfo Díez‐Pérez🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Harald Dobnig🇪🇸🇬🇷🇬🇧🇦🇹🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; Medical University of Graz; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Alison M. Dunning🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Anna Enjuanes🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Astrid Fahrleitner‐Pammer🇪🇸🇬🇷🇬🇧🇦🇹🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; Medical University of Graz; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Yue Fang🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; Erasmus University Rotterdam; University of Edinburgh
- Elżbieta Karczmarewicz🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇵🇱🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Children's Memorial Health Institute; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Marcin Kruk🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇵🇱🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Children's Memorial Health Institute; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Johannes P.T.M. van Leeuwen🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; Erasmus University Rotterdam; University of Edinburgh
- Carmelo Mavilia🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Joyce B. J. van Meurs🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; Erasmus University Rotterdam; University of Edinburgh
- Jon Mangion🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Oxagen (United Kingdom); Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Fiona E. McGuigan🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Huibert A. P. Pols🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; Erasmus University Rotterdam; University of Edinburgh
- Wilfried Renner🇪🇸🇬🇷🇬🇧🇦🇹🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; Medical University of Graz; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Fernando Rivadeneira🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; Erasmus University Rotterdam; University of Edinburgh
- Natasja M. van Schoor🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Vrije Universiteit Amsterdam; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Serena Scollen🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- Rachael E. Sherlock🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Oxagen (United Kingdom); Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- John P. A. Ioannidis🇪🇸🇬🇷🇬🇧🇳🇱🇩🇰🇮🇹Universitat Autònoma de Barcelona; University of Ioannina; University of Aberdeen; University of Cambridge; Western General Hospital; Erasmus MC; Aarhus University Hospital; Hospital Del Mar; University of Florence; Universitat de Barcelona; Foundation for Research and Technology Hellas; Amsterdam UMC Location Vrije Universiteit Amsterdam; University of Edinburgh
- and APOSS Investigators
- and EPOS Investigators
- and EPOLOS Investigators
- and FAMOS Investigators
- and LASA Investigators
- and Rotterdam Study Investigators
- for the GENOMOS Study*
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the genetic regulation of bone mineral density (BMD). However, the clinical impact of these variants remains unclear.
Objective
To evaluate the relation between VDR polymorphisms, BMD, and fractures.
Design
Prospective multicenter large-scale association study.
Setting
The Genetic Markers for Osteoporosis consortium, involving 9 European research teams.
Participants
26,242 participants (18,405 women).
Measurements
Cdx2 promoter, FokI, BsmI, ApaI, and TaqI polymorphisms; BMD at the femoral neck and the lumbar spine by dual x-ray absorptiometry; and fractures.
Results
Comparisons of BMD at the lumbar spine and femoral neck showed nonsignificant differences less than 0.011 g/cm2 for any genotype with or without adjustments. A total of 6067 participants reported a history of fracture, and 2088 had vertebral fractures. For all VDR alleles, odds ratios for fractures were very close to 1.00 (range, 0.98 to 1.02) and collectively the 95% CIs ranged from 0.94 (lowest) to 1.07 (highest). For vertebral fractures, we observed a 9% (95% CI, 0% to 18%; P = 0.039) risk reduction for the Cdx2 A-allele (13% risk reduction in a dominant model).
Limitations
The authors analyzed only selected VDR polymorphisms. Heterogeneity was detected in some analyses and may reflect some differences in collection of fracture data across cohorts. Not all fractures were related to osteoporosis.
Conclusions
The FokI, BsmI, ApaI, and TaqI VDR polymorphisms are not associated with BMD or with fractures, but the Cdx2 polymorphism may be associated with risk for vertebral fractures.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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