Prevention of complications related to traumatic brain injury in children and adolescents with creatine administration: an open label randomized pilot study
Sakellaris G, Kotsiou M, Tamiolaki M, Kalostos G, Tsapaki E, Spanaki M, Spilioti M, Charissis G, Evangeliou A
The Journal of trauma · 70 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-08-01 · J Trauma · vol. 61 · número 2 · págs. 322–329
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 114 citas · más que el 94% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Traumatic Brain Injury and Neurovascular Disturbances · Traumatic Brain Injury Research · Neurological Disorders and Treatments
- Palabras clave
- traumatic brain injury, creatine supplementation, neuroprotection, pediatric patients, adolescents, post-traumatic amnesia, cognitive function, functional recovery, complication prevention
- MeSH
- humans, brain injuries, creatine, neuroprotective agents, prospective studies, pilot projects, adolescent, child, child, preschool, infant
9 autores
- George Sakellaris🇬🇷University Hospital of Heraklion
- Maria Kotsiou🇬🇷Ippokrateio General Hospital of Thessaloniki; University Hospital of Heraklion
- Maria Tamiolaki🇬🇷Ippokrateio General Hospital of Thessaloniki; University Hospital of Heraklion
- George N. Kalostos🇬🇷Ippokrateio General Hospital of Thessaloniki; University Hospital of Heraklion
- E Tsapaki🇬🇷Ippokrateio General Hospital of Thessaloniki; University Hospital of Heraklion
- M Spanaki🇬🇷Ippokrateio General Hospital of Thessaloniki; University Hospital of Heraklion
- Martha G. Spilioti🇬🇷Ippokrateio General Hospital of Thessaloniki; University Hospital of Heraklion
- George Charissis🇬🇷Ippokrateio General Hospital of Thessaloniki; University Hospital of Heraklion
- Athanasios Evangeliou🇬🇷Ippokrateio General Hospital of Thessaloniki; University Hospital of Heraklion
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There has been an enormous focus on the discovery and development of neuroprotective agents that might have clinical relevance after traumatic brain injury (TBI). Based on experimental facts, we studied administration of creatine to patients with TBI.
Methods
A prospective, randomized, comparative, open-labeled pilot study of the possible neuroprotective effect of creatine was performed on 39 children and adolescents, aged between 1 to 18 years old, with TBI. The creatine was administered for 6 months, at a dose of 0.4 gr/kg in an oral suspension form every day. For categorical variables, we used the chi test to identify differences between controls and cases. Statistical significance was defined as a p value 0.1.
Results
The administration of creatine to children with TBI improved results in several parameters, including duration of post-traumatic amnesia (PTA), duration of intubation, intensive care unit (ICU) stay, disability, good recovery, self care, communication, locomotion, sociability, personality/behavior and neurophysical, and cognitive function. Significant improvement was recorded in the categories of Cognitive (p < 0.001), personality/behavior (p < 0.001), Self Care (p = 0.029), and communication (p = 0.018) aspects in all patients. No side effects were seen because of creatine administration.
Conclusion
Preliminary data suggest that the administration of creatine may be beneficial to patients with traumatic brain injury.
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