Effects of caffeine are more marked on daytime recovery sleep than on nocturnal sleep
Carrier J, Fernandez-Bolanos M, Robillard R, Dumont M, Paquet J, Selmaoui B, Filipini D
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 57 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Natural Sciences and Engineering Research Council of Canada
Según 2 financiadores declarados.
Publicación
- Publicado
- 2006-08-23 · Neuropsychopharmacology · vol. 32 · número 4 · págs. 964–972
- Editorial
- Springer Nature
- Citado
- 86 citas · más que el 94% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Sleep and Wakefulness Research · Coffee research and impacts
- Palabras clave
- caffeine, nocturnal sleep, sleep deprivation, circadian timing, slow-wave sleep, sleep latency, REM sleep, sleep efficiency, homeostatic sleep pressure, shift work, jet lag
- MeSH
- saliva, humans, sleep deprivation, caffeine, central nervous system stimulants, polysomnography, analysis of variance, cross-over studies, double-blind method, wakefulness, reaction time, sleep, circadian rhythm, adult, female, male
7 autores
- Julie Carrier🇨🇦 · autor de correspondenciaHôpital du Sacré-Cœur de Montréal
- Marta Fernandez‐Bolaños🇨🇦Hôpital du Sacré-Cœur de Montréal; Université de Montréal
- Rébecca Robillard🇨🇦Hôpital du Sacré-Cœur de Montréal; Université de Montréal
- Marie Dumont🇨🇦Hôpital du Sacré-Cœur de Montréal
- Jean Paquet🇨🇦Hôpital du Sacré-Cœur de Montréal
- Brahim Selmaoui🇨🇦Hôpital du Sacré-Cœur de Montréal
- Daniel Filipini🇨🇦Hôpital du Sacré-Cœur de Montréal
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine is often used to counteract sleepiness generated by sleep deprivation, jet lag, and shift-work, and is consumed at different times of day. Caffeine also has effects on sleep. However, little is known about the interaction between sleep deprivation, circadian timing, and caffeine consumption on sleep. In this study, we compared the effects of caffeine on nocturnal sleep initiated at habitual circadian time and on daytime recovery sleep. Thirty-four moderate caffeine consumers participated in both caffeine (200 mg) and placebo (lactose) conditions in a double-blind crossover design. Seventeen subjects followed their habitual sleep-wake cycle and slept in the laboratory during the night (Night), while 17 subjects were sleep deprived for one night and recovery sleep started in the morning (DayRec). All subjects received a capsule of 100 mg of caffeine (or placebo) 3 h before bedtime, and the remaining dose 1 h before bedtime. Compared to placebo, caffeine lengthened sleep latency, increased stage 1, and reduced stage 2 and slow-wave sleep (SWS) in both groups. However, caffeine reduced sleep efficiency more strongly in the DayRec group, and decreased sleep duration and REM sleep only in that group. The stronger effects of caffeine on daytime recovery sleep compared to nocturnal sleep are probably the consequence of the combined influence of increasing circadian wake propensity drive and the dissipation of homeostatic sleep pressure. We propose that the reduction of SWS by caffeine during daytime sleep increases the impact of the circadian wake signal on sleep. These results have implications for individuals using caffeine during night time.
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