The effect of preoperative magnesium supplementation on blood catecholamine concentrations in patients undergoing CABG
Pasternak K, Dabrowski W, Dobija J, Wrońskal J, Rzecki Z, Biernacka J
Magnesium research · 8 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-06-01 · Magnes Res · vol. 19 · número 2 · págs. 113–22
- Editorial
- National Institutes of Health
- Citado
- 12 citas · más que el 80% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Cardiac and Coronary Surgery Techniques · Hemodynamic Monitoring and Therapy
- Palabras clave
- magnesium supplementation, blood catecholamines, epinephrine, norepinephrine, coronary artery bypass grafting, extracorporeal circulation, hypomagnesemia, postoperative period
- MeSH
- humans, magnesium, epinephrine, norepinephrine, catecholamines, radioimmunoassay, preoperative care, coronary artery bypass, extracorporeal circulation, dietary supplements, aged, middle aged, male
6 autores
- Kazimierz Pasternak🇵🇱Medical University of Lublin
- Wojciech Dąbrowski
- J Dobija
- J Wrońskal
- Ziemowit Rzecki
- Jadwiga Biernacka
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
It is well known that magnesium (Mg) plays an important role in many physiological processes such as regulation of blood catecholamine concentrations, particularly epinephrine (E) and norepinephrine (NE). The complex character of extracorporeal circulation (ECC) with intraoperative normovolemic haemodilution (NH) may alter blood Mg levels, which is likely to result in disorders of E and NE. The aim of this study was to analyze the influence of preoperative Mg supplementation on E and NE in patients undergoing CABG.
Patients and methods
Forty male patients undergoing CABG under general anaesthesia were included. Patients were randomly divided into two groups: A--the patients receiving pre-operative magnesium supplementation and B--patients without pre-operative magnesium supplementation. The Mg, E and NE blood concentrations were measured in five stages: 1) before anesthesia after the radial artery cannulation, 2) during NH and ECC, 3) immediately after surgery, 4) in the morning of the 1st postoperative day, 5) in the morning of the 2nd postoperative day. The Mg levels were determined by spectrophotometric methods, E and NE were measured by radioimmunoassay methods.
Results
The CABG caused a decrease of Mg and an increase of E and NE in both groups, but the changes were significantly higher in group B.
Conclusions
1) CABG causes a decrease of Mg and an increase of E and NE; 2) Preoperative, oral supplementation of Mg substantially reduces intra- and postoperative disorders.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.