Optimal vitamin D status and serum parathyroid hormone concentrations in African American women
Aloia JF, Talwar SA, Pollack S, Feuerman M, Yeh JK
The American journal of clinical nutrition · 117 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (R01-AG015325); National Institute on Aging (AG15325)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2006-12-01 · Am J Clin Nutr · vol. 84 · número 3 · págs. 602–609
- Editorial
- Elsevier BV
- Citado
- 177 citas · más que el 96% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 81 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D status, 25-hydroxyvitamin D, parathyroid hormone, vitamin D threshold, vitamin D3 supplementation, bone loss, osteoporosis prevention, African American women, calcium intake, middle-aged women
- MeSH
- humans, osteoporosis, postmenopausal, calcium, dietary, parathyroid hormone, vitamin d, linear models, longitudinal studies, health status, nutritional status, postmenopause, dose-response relationship, drug, middle aged, female, meta-analysis as topic, black or african american
5 autores
- John F. Aloia🇺🇸 · autor de correspondenciaWinthrop-University Hospital
- Sonia A Talwar🇺🇸Winthrop-University Hospital
- Simcha Z Pollack🇺🇸Winthrop-University Hospital
- Martin Feuerman🇺🇸Winthrop-University Hospital
- James K. Yeh🇺🇸Winthrop-University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Optimal vitamin D status for the prevention of osteoporosis has been inferred from examinations of the serum 25-hydroxyvitamin D [25(OH)D] concentration below which there is an increase in serum parathyroid hormone (PTH).
Objective
The objectives of the study were to ascertain whether a threshold for serum 25(OH)D exists below which serum PTH increases and whether persons with 25(OH)D above this threshold have lower rates of bone loss than do persons with 25(OH)D below the threshold.
Design
The relation of serum 25(OH)D to serum PTH was analyzed in 208 African American women studied longitudinally for 3 y. These healthy women in midlife were randomly assigned to receive placebo or 800 IU vitamin D3/d; after 2 y, the vitamin D3 supplementation was increased to 2000 IU/d. Both groups received calcium supplements to ensure an adequate calcium intake. A systematic literature review found a wide range of threshold values in part due to varied calcium intake.
Results
A Loess plot suggested a breakpoint between 40 and 50 nmol/L for serum 25(OH)D. A line-line model was fitted to the data, and it showed a spline knot at 44 nmol/L. A heuristic approach verified that PTH does not decline as rapidly when the serum concentration of 25(OH)D is >40 nmol/L as when it is <40 nmol/L. We found no significant difference in rates of bone loss between persons with 25(OH)D concentrations above and below 40 nmol/L.
Conclusion
Although a threshold for 25(OH)D can be identified, we suggest that it should not be used to recommend optimal vitamin D status.
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