Effect of dietary virgin olive oil on urinary excretion of etheno-DNA adducts
Hillestrøm PR, Covas MI, Poulsen HE
Free radical biology & medicine · 22 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
- Subvenciones
- European Commission (QLK1-CT-2001-00287)
Según 1 financiador declarado.
Publicación
- Publicado
- 2006-07-05 · Free Radic Biol Med · vol. 41 · número 7 · págs. 1133–1138
- Editorial
- Elsevier BV
- Citado
- 43 citas · más que el 92% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Edible Oils Quality and Analysis · Phytochemicals and Antioxidant Activities · Antioxidant Activity and Oxidative Stress
- Palabras clave
- virgin olive oil, etheno-DNA adducts, urinary excretion, oxidative DNA damage, phenolic compounds, lipid peroxidation, oxidative stress, linoleic acid, omega-6 fatty acids, Mediterranean diet, dietary antioxidants, chemoprevention
- MeSH
- humans, ethylenes, dietary fats, unsaturated, plant oils, dna adducts, adult, middle aged, male, biomarkers, olive oil
3 autores
- Peter R. Hillestrøm🇩🇰Copenhagen University Hospital; Rigshospitalet
- María‐Isabel Covas
- Henrik Enghusen Poulsen🇩🇰 · autor de correspondenciaCopenhagen University Hospital; Rigshospitalet
Resumen
El texto original del estudio, en el idioma en que se publicó.
A significant protective effect against cancer and coronary heart disease has been attributed to the Mediterranean diet, in which olive oil is the main source of fat. Dietary antioxidants, as phenolic compounds from virgin olive oil, are candidates for reducing cancer risk by minimizing oxidatively derived DNA damage. Etheno-DNA adducts are formed as a result of oxidative stress and lipid peroxidation. To evaluate whether phenol-rich virgin olive oil influences urinary excretion of the etheno-DNA adducts epsilonAde, epsilondA, and epsilondC as markers of oxidative stress, a randomized, double-blinded, crossover trial with three intervention periods was conducted in 28 healthy men. Each intervention was of 3 weeks' duration and separated by 2-week washout periods. Twenty-five milliliters of similar olive oils, but with differences in their phenolic content (from 2.7 to 366 mg/kg), were supplied to each subject per day. The urinary excretion of the DNA adducts was assayed by LC-MS/MS in samples before and after consumption of high phenolic content olive oil (virgin). The 24-h excretion rate did not differ significantly between baseline and after virgin olive oil consumption: epsilonAde, 105.5 +/- 40.8 vs 116.4 +/- 53.4 pmol epsilonAde/24 h (p = 0.21); epsilondA, 37.9 +/- 24.8 vs 37.6 17 +/- 24.2 pmol epsilondA/24 h (p = 0.93); and epsilondC, 218.7 +/- 157.2 vs 193.5 +/- 64.7 pmol epsilondC/24 h (p = 0.37). Multiple regression analysis showed a significant association between etheno-DNA adduct excretion rate and the dietary intake of linoleic acid (C18:2, omega-6) in healthy men. Consumption of 25 ml per day of phenol-rich virgin olive oil for 3 weeks did not modify to a significant degree the urinary excretion of etheno-DNA adducts in 28 healthy volunteers.
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