Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins
Larqué E, Krauss-Etschmann S, Campoy C, Hartl D, Linde J, Klingler M, Demmelmair H, Caño A, Gil A, Bondy B, Koletzko B
The American journal of clinical nutrition · 100 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-10-01 · Am J Clin Nutr · vol. 84 · número 4 · págs. 853–861
- Editorial
- Elsevier BV
- Citado
- 155 citas · más que el 96% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and biosynthesis · Birth, Development, and Health
- Palabras clave
- docosahexaenoic acid, pregnancy, placenta, fatty acid transporters, fatty acid translocase, fatty acid binding protein, long-chain polyunsaturated fatty acids, maternal DHA supplementation, eicosapentaenoic acid, 5-methyltetrahydrofolate, preterm birth
- MeSH
- placenta, humans, docosahexaenoic acids, rna, messenger, double-blind method, polymerase chain reaction, pregnancy, adult, female, fatty acid-binding proteins, fatty acid transport proteins
11 autores
- Elvira Larqué🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Susanne Krauss‐Etschmann🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Cristina Campoy🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Dominik Hartl🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Javier Linde🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Mario Klingler🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Hans Demmelmair🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- África Caño🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Ángel Gil🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Brigitta Bondy🇪🇸🇩🇪Universidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
- Berthold Viktor Koletzko🇪🇸🇩🇪 · autor de correspondenciaUniversidad de Granada; Helmholtz Munich; Ludwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Better understanding of the mechanisms involved in docosahexaenoic acid (DHA) transfer to the neonate may contribute to improve dietary support for infants born prematurely to mothers with placental lipid transport disorders.
Objective
We studied whether DHA supplements modify the messenger RNA (mRNA) expression of placental lipid transport proteins to allow a selective transfer of DHA to the fetus.
Design
Healthy pregnant women (n = 136) received, in a double-blind randomized trial, 500 mg DHA + 150 mg eicosapentaenoic acid, 400 microg 5-methyl-tetrahydrofolic acid, 500 mg DHA + 400 microg 5-methyl-tetrahydrofolic acid, or placebo during the second half of gestation. We analyzed the fatty acid composition of maternal and cord blood phospholipids and of placenta; we quantified placental mRNA expression of fatty acid-transport protein 1 (FATP-1), FATP-4, FATP-6, fatty acid translocase, fatty acid-binding protein (FABP) plasma membrane, heart-FABP, adipocyte-FABP, and brain-FABP.
Results
The mRNA expression of the lipid carriers assayed did not differ significantly between the 4 groups. However, the mRNA expression of FATP-1 and FATP-4 in placenta was correlated with DHA in both maternal plasma and placental phospholipids, although only FATP-4 expression was significantly correlated with DHA in cord blood phospholipids. Additionally, the mRNA expression of several membrane lipid carriers was correlated with EPA and DHA in placental triacylglycerols and with EPA in placental free fatty acids.
Conclusions
Correlation of the mRNA expression of the membrane placental proteins FATP-1 and especially of FATP-4 with maternal and cord DHA leads us to conclude that these lipid carriers are involved in placental transfer of long-chain polyunsaturated fatty acids.
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