Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function
Cortés B, Núñez I, Cofán M, Gilabert R, Pérez-Heras A, Casals E, Deulofeu R, Ros E
Journal of the American College of Cardiology · 148 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Fundación Carolina
Según 1 financiador declarado.
Publicación
- Publicado
- 2006-09-27 · J Am Coll Cardiol · vol. 48 · número 8 · págs. 1666–1671
- Editorial
- Elsevier BV
- Citado
- 239 citas · más que el 99% de estudios similares · 11.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 22 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nitric Oxide and Endothelin Effects · Fatty Acid Research and Health
- Palabras clave
- Juglans regia, olive oil, high-fat meal, flow-mediated dilation, hypercholesterolemia, asymmetric dimethylarginine, oxidized LDL, triglycerides, E-selectin, adhesion molecules, inflammation, brachial artery, Mediterranean diet
- MeSH
- brachial artery, endothelium, vascular, humans, juglans, nuts, hypercholesterolemia, dietary fats, triglycerides, lipoproteins, ldl, plant oils, cell adhesion molecules, e-selectin, inflammation mediators, cytokines, fasting, cross-over studies, regional blood flow, vasodilation, postprandial period, dose-response relationship, drug, osmolar concentration, olive oil
8 autores
- B. Cortés🇪🇸Universitat Autònoma de Barcelona
- Isabel Núñez
- Montserrat Cofán
- Rosa Gilabert
- Ana Pérez-Heras
- Elena Casals🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Ramón Deulofeu🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Emilio Ros · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
We sought to investigate whether the addition of walnuts or olive oil to a fatty meal have differential effects on postprandial vasoactivity, lipoproteins, markers of oxidation and endothelial activation, and plasma asymmetric dimethylarginine (ADMA).
Background
Compared with a Mediterranean diet, a walnut diet has been shown to improve endothelial function in hypercholesterolemic patients. We hypothesized that walnuts would reverse postprandial endothelial dysfunction associated with consumption of a fatty meal.
Methods
We randomized in a crossover design 12 healthy subjects and 12 patients with hypercholesterolemia to 2 high-fat meal sequences to which 25 g olive oil or 40 g walnuts had been added. Both test meals contained 80 g fat and 35% saturated fatty acids, and consumption of each meal was separated by 1 week. Venipunctures and ultrasound measurements of brachial artery endothelial function were performed after fasting and 4 h after test meals.
Results
In both study groups, flow-mediated dilation (FMD) was worse after the olive oil meal than after the walnut meal (p = 0.006, time-period interaction). Fasting, but not postprandial, triglyceride concentrations correlated inversely with FMD (r = -0.324; p = 0.024). Flow-independent dilation and plasma ADMA concentrations were unchanged, and the concentration of oxidized low-density lipoproteins decreased (p = 0.051) after either meal. The plasma concentrations of soluble inflammatory cytokines and adhesion molecules decreased (p < 0.01) independently of meal type, except for E-selectin, which decreased more (p = 0.033) after the walnut meal.
Conclusions
Adding walnuts to a high-fat meal acutely improves FMD independently of changes in oxidation, inflammation, or ADMA. Both walnuts and olive oil preserve the protective phenotype of endothelial cells.
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