Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids
Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY
Clinical chemistry · 269 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-10-20 · Clin Chem · vol. 52 · número 12 · págs. 2265–2272
- Editorial
- American Association for Clinical Chemistry
- Citado
- 351 citas · más que el 98% de estudios similares · 9.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, erythrocyte membrane, plasma phospholipids, omega-3 index, fish oil supplementation, linseed oil, alpha-linolenic acid, fatty acid incorporation, cardiovascular risk
- MeSH
- erythrocyte membrane, plasma, humans, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, linseed oil, phospholipids, fish oils, single-blind method, dietary supplements, middle aged, female, male
4 autores
- Jing Cao🇺🇸University of Minnesota
- Kerry Schwichtenberg🇺🇸University of Minnesota
- Naomi Quast Hanson🇺🇸University of Minnesota
- Michael Y. Tsai🇺🇸 · autor de correspondenciaUniversity of Minnesota
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The sum of eicosapentaenoic acid (EPA, 20:5 omega3) and docosahexaenoic acid (DHA, 22:6 omega3) in erythrocyte membranes, termed the omega-3 index, can indicate suboptimal intake of omega-3 fatty acids, a risk factor for cardiovascular disease (CVD). To study the effects of fatty acid supplementation, we investigated the rate of incorporation and clearance of these fatty acids in erythrocyte membranes and plasma after intake of supplements.
Methods
Twenty study participants received supplementation with either fish oil (1296 mg EPA + 864 mg DHA/day) or flaxseed oil (3510 mg alpha-linolenic acid + 900 mg linoleic acid/day) for 8 weeks. We obtained erythrocyte membrane and plasma samples at weeks 0, 4, 8, 10, 12, 14, 16, and 24 and extracted and analyzed fatty acids by gas chromatography.
Results
After 8 weeks of fish oil supplementation, erythrocyte membrane EPA and DHA increased 300% (P < 0.001) and 42% (P < 0.001), respectively. The mean erythrocyte omega-3 index reached a near optimal value of 7.8%, and remained relatively high until week 12. EPA and DHA showed greater increases and more rapid washout period decreases in plasma phospholipids than in erythrocyte membranes. Flaxseed oil supplementation increased erythrocyte membrane EPA to 133% (P < 0.05) and docosapentaenoic acid (DPA, 22:5 omega3) to 120% (P < 0.01) of baseline, but DHA was unchanged. In plasma phospholipids, EPA, DPA, and DHA showed a slight but statistically insignificant increase.
Conclusions
Erythrocyte membrane EPA+DHA increases during relatively short intervals in response to supplementation at rates related to amount of supplementation. These results may be useful to establish appropriate dosage for omega-3 fatty acid supplementation.
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