The effects of nicotine on the metabolic and hormonal responses during acute cold exposure
Cheatham CC, Caine-Bish N, Blegen M, Potkanowicz ES, Kamimori GH, Marcinkiewicz JL, Otterstetter R, Kalinski M, Glickman EL
Wilderness & environmental medicine · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wilderness Medical Society
Según 1 financiador declarado.
Publicación
- Publicado
- 2006-01-01 · Wilderness Environ Med · vol. 17 · número 3 · pág. 147
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 22% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Adipose Tissue and Metabolism · Thermoregulation and physiological responses · Smoking Behavior and Cessation
- Palabras clave
- nicotine, cold exposure, cold acclimatization, norepinephrine, epinephrine, cortisol, free fatty acids, glucose, glycerol, thermoregulation, sympathetic nervous system, sex differences
- MeSH
- humans, norepinephrine, glycerol, nicotine, hydrocortisone, hormones, blood glucose, fatty acids, nonesterified, area under curve, cross-over studies, sex factors, body temperature regulation, adult, female, male, cold temperature
9 autores
- Christopher C. Cheatham🇺🇸Western Michigan University; Kent State University
- Natalie L. Caine-Bish🇺🇸Western Michigan University; Kent State University
- Mark D. Blegen🇺🇸Western Michigan University; Kent State University
- Edward S. Potkanowicz🇺🇸Western Michigan University; Kent State University
- Gary H. Kamimori🇺🇸Western Michigan University; Kent State University
- Jennifer L. Marcinkiewicz🇺🇸Western Michigan University; Kent State University
- Ronald Otterstetter🇺🇸Western Michigan University; Kent State University
- MICHAEL I. KALINSKI🇺🇸Western Michigan University; Kent State University
- Ellen L. Glickman🇺🇸Western Michigan University; Kent State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the effects of nicotine on the metabolic and hormonal responses during acute cold exposure.
Methods
Participants in this study included 6 men and 5 women between the ages of 19 and 25 years. Each subject performed 2 cold-air trials (CATs) consisting of a 30-minute baseline (BASE) period and a 120-minute exposure to 10 degree C air. One CAT was performed after a nicotine (NIC) dosing using a 21-mg transdermal patch, whereas the other CAT was performed after a placebo (PL) treatment. Blood samples for metabolic and hormonal measurements were obtained at the end of BASE and immediately after the cold exposure.
Results
When examining the sexes separately, there was no difference in norepinephrine between PL and NIC (P = .066). There was also no difference in epinephrine between PL and NIC in either sex (P = .634). From BASE to 120 minutes of the CAT, there was a significant decrease in cortisol (P = .036), but this response was similar between the 2 treatments (P = .077). Glucose and glycerol concentrations were not different between the PL and NIC treatments. At BASE, nonesterified fatty acid (NEFA) concentration was lower during PL compared with NIC (P = .021); however, at 120 minutes of the CAT, NEFA was greater during PL compared with NIC (P = .035).
Conclusions
During 120 minutes of cold exposure, NIC resulted in alterations in the responses in NEFA, whereas the other blood measurements were not significantly different between the 2 groups.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.