Does caffeine modify corticomotor excitability?
Cerqueira V, de Mendonça A, Minez A, Dias AR, de Carvalho M
Neurophysiologie clinique = Clinical neurophysiology · 42 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-07-01 · Neurophysiol Clin · vol. 36 · número 4 · págs. 219–226
- Editorial
- Elsevier BV
- Citado
- 54 citas · más que el 72% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Transcranial Magnetic Stimulation Studies · Coffee research and impacts · Neuroscience and Neuropharmacology Research
- Palabras clave
- caffeine, corticomotor excitability, cortical silent period, motor evoked potentials, F-wave, lower motor neurons, upper motor neurons, central conduction time, abductor digiti minimi, biceps brachii, caffeine dose-response, caffeine dependence
- MeSH
- muscle, skeletal, motor cortex, spinal cord, motor neurons, peripheral nerves, humans, caffeine, central nervous system stimulants, electroencephalography, double-blind method, evoked potentials, motor, stimulation, chemical, electromagnetic fields, adult, female, male, transcranial magnetic stimulation
5 autores
- Vitor Barbosa Cerqueira🇵🇹Hospital de Santa Maria
- Alexandre de Mendonça🇵🇹University of Lisbon; Hospital de Santa Maria; Instituto de Medicina Molecular João Lobo Antunes
- A. Minez🇵🇹Hospital of St. Francis Xavier
- Ângela R. Mantas Dias🇵🇹Hospital of St. Francis Xavier
- Mamede A. de Carvalho🇵🇹 · autor de correspondenciaHospital de Santa Maria; Instituto de Medicina Molecular João Lobo Antunes
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To test the influence of caffeine on the lower and upper motor neuron excitability.
Methods
In Experiment A, 18 healthy subjects received 200 mg of caffeine or placebo, in a randomized, double-blind, placebo-controlled design protocol. Mean F-waves amplitude, amplitude of the motor response evoked by magnetic stimulation (MEP), MEP duration, cortical silent period (CSP), central conduction time, and cortical threshold were evaluated. In Experiment B, 6 healthy controls received 400 mg of caffeine, the peripheral silent period (PSP) and CSP were evaluated. CSP was recorded bilaterally in biceps brachii (intensity 10% above threshold) and abductor digiti minimi (ADM) (intensity at 10% and 50% above threshold). Muscle contraction was above 50% of the maximum force in both experiments. Latencies were defined by a technician who was not aware of this investigation. Serum caffeine level was evaluated.
Results
In Experiment A, only the CSP, recorded in both ADM with intensity at 10% above threshold showed a significant change after caffeine (decrease of 17.1+/-34.0 ms, about 12% reduction). In Experiment B, PSP did not change, but CSP tested with intensities 10% above threshold was significantly decreased by 20.8+/-34.4 ms in ADM and 13.5+/-13.8 ms in biceps (about 13 and 16%, respectively). Serum caffeine level clearly increased after consumption but no correlation could be found between these levels and CSP reduction.
Conclusions
In our investigation, caffeine elicited a consistent decrease of the CSP, suggesting that caffeine increases cortical neuronal excitability.
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