Effects of acute administration of caffeine on vascular function
Umemura T, Ueda K, Nishioka K, Hidaka T, Takemoto H, Nakamura S, Jitsuiki D, Soga J, Goto C, Chayama K, Yoshizumi M, Higashi Y
The American journal of cardiology · 124 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-10-18 · Am J Cardiol · vol. 98 · número 11 · págs. 1538–1541
- Editorial
- Elsevier BV
- Citado
- 189 citas · más que el 94% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 13 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- caffeine, endothelial function, endothelium-dependent vasodilation, forearm blood flow, nitric oxide, L-NMMA, acetylcholine, sodium nitroprusside, blood pressure, hypertension
- MeSH
- forearm, endothelium, vascular, humans, nitroprusside, acetylcholine, caffeine, omega-n-methylarginine, vasodilator agents, enzyme inhibitors, plethysmography, double-blind method, blood pressure, heart rate, vasodilation, adult, male
12 autores
- Takashi Umemura🇯🇵Hiroshima University
- Keiko Ueda🇯🇵Hiroshima University
- Kenji Nishioka🇯🇵Hiroshima University
- Takayuki Hidaka🇯🇵Hiroshima University
- Hiroaki Takemoto🇯🇵Hiroshima University
- Shuji Nakamura🇯🇵Hiroshima University
- Daisuke Jitsuiki🇯🇵Hiroshima University
- Junko Soga🇯🇵Hiroshima University
- Chikara Goto🇯🇵Hiroshima University
- Kazuaki Chayama🇯🇵Hiroshima University
- Masao Yoshizumi🇯🇵Hiroshima University
- Yukihito Higashi🇯🇵 · autor de correspondenciaHiroshima University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine is the most widely used pharmacologic substance in the world. It is found in common nonessential grocery items (e.g., coffee, tea, cocoa, and chocolate). The effects of caffeine on cardiovascular diseases, including hypertension, remain controversial, and there is little information on its direct effect on vascular function. The purpose of this study was to determine the effect of caffeine on endothelial function in humans. This study was a double-blind, randomized placebo and active drug study. Forearm blood flow (FBF) responses to acetylcholine (ACh), an endothelium-dependent vasodilator, and to sodium nitroprusside, an endothelium-independent vasodilator, were evaluated in healthy young men before and after the oral administration of caffeine 300 mg (n = 10) or placebo (n = 10). FBF was measured by using a strain-gauge plethysmograph. Caffeine significantly increased systolic and diastolic blood pressures by 6.0 +/- 6.0 and 2.6 +/- 3.1 mm Hg (p <0.05), respectively, but did not alter heart rate or baseline FBF. Caffeine augmented the FBF responses to ACh from 21.2 +/- 7.1 to 26.6 +/- 8.1 ml/min/100 ml tissue (p <0.05), whereas sodium nitroprusside-stimulated vasodilation was not altered by caffeine administration. The intra-arterial infusion of N(G)-monomethyl-L-arginine, a nitric oxide synthase inhibitor, abolished the caffeine-induced augmentation of FBF response to ACh. In the placebo group, the ACh- and sodium nitroprusside-stimulated vasodilation was similar before and after the follow-up period. In conclusion, these findings suggest that the acute administration of caffeine augments endothelium-dependent vasodilation in healthy young men through an increase in nitric oxide production.
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