Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trial
Dunstan JA, Simmer K, Dixon G, Prescott SL
Archives of disease in childhood. Fetal and neonatal edition · 202 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-12-21 · Arch Dis Child Fetal Neonatal Ed · vol. 93 · número 1 · págs. F45–F50
- Editorial
- BMJ
- Citado
- 338 citas · más que el 99% de estudios similares · 12.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Child Nutrition and Water Access
- Palabras clave
- omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, prenatal nutrition, infant cognitive development, infant growth, arachidonic acid, omega-6 fatty acids, child behavior, receptive language
- MeSH
- humans, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fish oils, double-blind method, child development, cognition, psychomotor performance, pregnancy, dietary supplements, adult, child, preschool, western australia, female, prenatal nutritional physiological phenomena
4 autores
- Janet A. Dunstan🇦🇺The University of Western Australia
- Karen Norrie Simmer🇦🇺The University of Western Australia
- Glenys Dixon🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Susan L. Prescott🇦🇺 · autor de correspondenciaThe University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To assess the effects of antenatal omega 3 long-chain polyunsaturated fatty acid (n-3 LC PUFA) on cognitive development in a cohort of children whose mothers received high-dose fish oil in pregnancy.
Design
A double-blind randomised placebo-controlled trial.
Setting
Perth, Western Australia, Australia.
Patients
98 pregnant women received the supplementation from 20 weeks' gestation until delivery. Their infants (n = 72) were assessed at age 2(1/2) years.
Interventions
Fish oil (2.2 g docosahexaenoic acid (DHA) and 1.1 g eicosapentaenoic acid (EPA)/day) or olive oil from 20 weeks' gestation until delivery.
Outcome measures
Effects on infant growth and developmental quotients (Griffiths Mental Development Scales), receptive language (Peabody Picture Vocabulary Test) and behaviour (Child Behaviour Checklist).
Results
Children in the fish oil-supplemented group (n = 33) attained a significantly higher score for eye and hand coordination (mean ((SD) score 114 (10.2)) than those in the placebo group (n = 39, mean score 108 (SD 11.3); p = 0.021, adjusted p = 0.008). Eye and hand coordination scores correlated with n-3 PUFA levels in cord blood erythrocytes (EPA: r = 0.320, p = 0.007; DHA: r = 0.308, p = 0.009) and inversely correlated with n-6 PUFA (arachidonic acid 20:4n-6: r = -0.331, p = 0.005). Growth measurements in the two groups were similar at age 2(1/2) years.
Conclusion
Maternal fish oil supplementation during pregnancy is safe for the fetus and infant, and may have potentially beneficial effects on the child's eye and hand coordination. Further studies are needed to determine the significance of this finding.
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