Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations
Major GC, Alarie F, Doré J, Phouttama S, Tremblay A
The American journal of clinical nutrition · 174 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-01-01 · Am J Clin Nutr · vol. 85 · número 1 · págs. 54–9
- Editorial
- National Institutes of Health
- Citado
- 251 citas · más que el 99% de estudios similares · 11.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Nutritional Studies and Diet
- Palabras clave
- calcium supplementation, vitamin D supplementation, weight loss, plasma lipids, lipoproteins, HDL cholesterol, LDL cholesterol, LDL/HDL ratio, triglycerides, total cholesterol, caloric restriction, overweight women, obese women, low calcium intake, glucose tolerance, insulin
- MeSH
- humans, obesity, weight loss, calcium, dietary, insulin, blood glucose, lipids, lipoproteins, vitamin d, diet, reducing, double-blind method, blood pressure, drug synergism, dietary supplements, adult, female, bone density conservation agents, hyperlipidemias
5 autores
- Geneviève C. Major🇨🇦Université Laval
- Francine P. Alarie🇨🇦Université Laval
- Jean Doré🇨🇦Université Laval
- Sakouna Phouttama🇨🇦Université Laval
- Angelo Tremblay🇨🇦Université Laval
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Adequate calcium intake can have a favorable effect on some metabolic variables.
Objective
The objective of the study was to determine the effects of daily calcium intake and of supplementation with calcium and vitamin D (calcium+D) during a weight-loss intervention on blood pressures, plasma lipid and lipoprotein concentrations, and glucose and insulin concentrations in low calcium consumers.
Design
Healthy, overweight or obese women (n = 63) with a daily calcium intake of < 800 mg/d were randomly assigned in a double-blind manner to 1 of 2 groups: the group consuming 2 tablets/d of a calcium + vitamin D supplement (600 mg elemental calcium and 200 IU vitamin D/tablet) or the group consuming placebo; both groups observed a 700 kcal/d energy restriction. These 63 women then completed a 15-wk weight-loss intervention.
Results
Initial daily calcium intake was significantly correlated with plasma HDL cholesterol (r = 0.41, P < 0.001) and with 2-h postload glycemia (r = -0.29, P < 0.05) during an oral-glucose-tolerance test, independent of fat mass and waist circumference. After the 15-wk intervention, significantly greater decreases in total:LDL and LDL:HDL (P < 0.01 for both) and of LDL cholesterol (P < 0.05) were observed in the calcium+D group than in the placebo group. The differences in total:HDL and LDL:HDL were independent of changes in fat mass and in waist circumference. A tendency for more beneficial changes in HDL cholesterol, triacylglycerol, and total cholesterol was also observed in the calcium+D group (P = 0.08).
Conclusion
Consumption of calcium+D during a weight-loss intervention enhanced the beneficial effect of body weight loss on the lipid and lipoprotein profile in overweight or obese women with usual low daily calcium intake.
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