Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas
Courtney ED, Matthews S, Finlayson C, Di Pierro D, Belluzzi A, Roda E, Kang JY, Leicester RJ
International journal of colorectal disease · 80 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-01-09 · Int J Colorectal Dis · vol. 22 · número 7 · págs. 765–776
- Editorial
- Springer Science+Business Media
- Citado
- 125 citas · más que el 99% de estudios similares · 12.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Inflammatory mediators and NSAID effects · Colorectal Cancer Screening and Detection
- Palabras clave
- eicosapentaenoic acid, omega-3 fatty acids, fish oil supplementation, colorectal adenoma, crypt cell proliferation, apoptosis, colonic mucosa, colorectal cancer chemoprevention, dietary supplementation
- MeSH
- intestinal mucosa, colon, humans, adenoma, colorectal neoplasms, eicosapentaenoic acid, fatty acids, colonoscopy, biopsy, treatment outcome, immunohistochemistry, administration, oral, retrospective studies, follow-up studies, apoptosis, cell proliferation, middle aged, female, male
8 autores
- E. D. Courtney🇬🇧 · autor de correspondenciaSt George's Hospital; Luton and Dunstable Hospital; St George's Hospital
- S. Matthews🇬🇧St George's Hospital; St George's Hospital
- Caroline J. Finlayson🇬🇧St George's Hospital; St George's Hospital
- Donato Di Pierro🇮🇹University of Bologna
- Andrea Belluzzi🇮🇹University of Bologna
- E. Roda🇮🇹University of Bologna
- Jin-Yong Kang🇬🇧St George's Hospital; St George's Hospital
- Roger J. Leicester🇬🇧St George's Hospital; St George's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Omega-3 fatty acids in fish oil exert a protective effect on the development of colorectal cancer in animal models. Patients with colorectal adenomas have been shown to have increased crypt cell proliferation and decreased apoptosis in macroscopically normal appearing colonic mucosa. We investigated whether dietary supplementation with eicosapentaenoic acid (EPA) could alter crypt cell proliferation and apoptosis in such patients.
Patients/methods
Thirty subjects were randomised to either 3 months of highly purified EPA in free fatty acid form (2 g/day) or to no treatment. Colonic biopsies were taken at the initial colonoscopy and repeated 3 months later, and analysed for cell proliferation and apoptosis (immunohistochemistry) and mucosal fatty acid content.
Results/findings
Crypt cell proliferation was significantly reduced whilst apoptosis was significantly increased after EPA supplementation. Neither crypt cell proliferation nor apoptosis were altered in the control group. EPA in the mucosa increased significantly after EPA supplementation, whereas there was no significant change in controls.
Conclusions
Dietary supplementation with EPA significantly increases levels of this fatty acid in colonic mucosa, associated with significantly reduced proliferation and increased mucosal apoptosis. Further studies are needed to assess the potential efficacy of EPA supplementation in preventing polyps in the chemoprevention of colorectal cancer.
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