Effect of reducing caffeine intake on birth weight and length of gestation: randomised controlled trial
Bech BH, Obel C, Henriksen TB, Olsen J
BMJ (Clinical research ed.) · 71 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- March of Dimes Foundation
- Gobierno
- National Research Foundation
- Gobierno
- Danmarks Grundforskningsfond
- Organización sin fines de lucro
- Augustinus Fonden
- Organización sin fines de lucro
- Egmont Fonden
Según 5 financiadores declarados.
Publicación
- Publicado
- 2007-01-26 · BMJ · vol. 334 · número 7590 · pág. 409
- Citado
- 135 citas · más que el 98% de estudios similares · 8.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Prenatal Substance Exposure Effects · Pregnancy and Medication Impact
- Palabras clave
- caffeine consumption, pregnancy, birth weight, gestation length, decaffeinated coffee, instant coffee, coffee consumption
- MeSH
- humans, pregnancy complications, birth weight, caffeine, pregnancy outcome, double-blind method, patient compliance, maternal exposure, gestational age, pregnancy, coffee, adult, female
4 autores
- Bodil Hammer Bech🇩🇰 · autor de correspondenciaAarhus University
- Carsten Obel🇩🇰Aarhus University
- Tine Brink Henriksen🇩🇰Aarhus University Hospital
- Jørn Olsen🇺🇸University of California, Los Angeles
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To estimate the effect of reducing caffeine intake during pregnancy on birth weight and length of gestation.
Design
Randomised double blind controlled trial.
Setting
Denmark.
Participants
1207 pregnant women drinking at least three cups of coffee a day, recruited before 20 weeks' gestation.
Interventions
Caffeinated instant coffee (568 women) or decaffeinated instant coffee (629 women).
Main outcome measures
Birth weight and length of gestation.
Results
Data on birth weight were obtained for 1150 liveborn singletons and on length of gestation for 1153 liveborn singletons. No significant differences were found for mean birth weight or mean length of gestation between women in the decaffeinated coffee group (whose mean caffeine intake was 182 mg lower than that of the other group) and women in the caffeinated coffee group. After adjustment for length of gestation, parity, prepregnancy body mass index, and smoking at entry to the study the mean birth weight of babies born to women in the decaffeinated group was 16 g (95% confidence interval -40 to 73) higher than those born to women in the caffeinated group. The adjusted difference (decaffeinated group-caffeinated group) of length of gestation was -1.31 days (-2.87 to 0.25).
Conclusion
A moderate reduction in caffeine intake in the second half of pregnancy has no effect on birth weight or length of gestation.
Trial registration
Clinical Trials NCT00131690 [ClinicalTrials.gov].
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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