Evaluation of clinical safety and beneficial effects of a fish oil containing lipid emulsion (Lipoplus, MLF541): data from a prospective, randomized, multicenter trial
Wichmann MW, Thul P, Czarnetzki HD, Morlion BJ, Kemen M, Jauch KW
Critical care medicine · 112 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-02-23 · Crit Care Med · vol. 35 · número 3 · págs. 700–706
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 179 citas · más que el 99% de estudios similares · 11.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Enhanced Recovery After Surgery
- Palabras clave
- fish oil lipid emulsion, omega-3 fatty acids, parenteral nutrition, major abdominal surgery, postoperative care, Intralipid, eicosapentaenoic acid, leukotriene B5, alpha-tocopherol, length of hospital stay, clinical safety, long-chain polyunsaturated fatty acids
- MeSH
- abdomen, humans, postoperative complications, eicosapentaenoic acid, fat emulsions, intravenous, fatty acids, unsaturated, leukotrienes, phospholipids, fish oils, alpha-tocopherol, amino acids, treatment outcome, parenteral nutrition, total, critical care, length of stay, postoperative care, hospital mortality, survival rate, prospective studies, adult, aged, middle aged, intensive care units, germany, female, male
6 autores
- Matthias W. Wichmann🇩🇪LMU Klinikum; Ludwig-Maximilians-Universität München
- Paul Thul🇩🇪Ludwig-Maximilians-Universität München
- H.-D. Czarnetzki🇩🇪Ludwig-Maximilians-Universität München
- Bart J. Morlion🇩🇪Ludwig-Maximilians-Universität München
- Matthias Kemen🇩🇪Ludwig-Maximilians-Universität München
- Karl‐Walter Jauch🇩🇪Ludwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To prove safety and effectiveness of a lipid emulsion enriched with n-3 fatty acids from fish oil (Lipoplus) within the setting of parenteral nutrition of patients after major abdominal surgery and to determine whether there are effects on outcome parameters.
Design
Prospective, randomized, double-blind, multicenter trial.
Setting
University and surgical teaching hospitals.
Patients
After obtaining informed consent, 256 patients undergoing major abdominal surgery were randomized. Parameters of safety, effectiveness, and outcome were routine laboratory parameters, complication rates, length of stay in the intensive care unit, and length of hospital stay. In addition we determined in patient subgroups of 30 patients each, the changes of the content of selected long-chain polyunsaturated fatty acids, the leukotriene synthetic capacity and the antioxidant alpha-tocopherol.
Interventions
Participating patients were randomized to receive either Lipoplus (group I; n = 127 patients) or Intralipid (group II; n = 129 patients). Parenteral nutrition was initiated immediately after surgery and ended on day 5 after surgery.
Measurements and main results
No significant differences between groups I and II were observed when comparing routine laboratory parameters during the perioperative period. Plasma levels of eicosapentaenoic acid, leukotriene B5, and antioxidant content were significantly increased in group I. Furthermore, there was a significantly shorter length of hospital stay of approximately 21% (17.2 vs. 21.9 days; p = .0061) in group I.
Conclusions
Our findings indicate that the administration of Lipoplus in the postoperative period after major abdominal surgery is safe and results in a significantly shorter length of hospital stay. Administration of n-3 polyunsaturated fatty acids in the postoperative period can be considered a valuable choice for patients requiring parenteral nutrition after major abdominal surgery.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.