Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials
Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P
The Journal of clinical endocrinology and metabolism · 311 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-02-02 · J Clin Endocrinol Metab · vol. 92 · número 4 · págs. 1415–1423
- Editorial
- Oxford University Press
- Citado
- 537 citas · más que el 100% de estudios similares · 37.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin K Research Studies
- Palabras clave
- hip fracture, vitamin D supplementation, calcium supplementation, osteoporosis prevention, postmenopausal women, older men, fracture risk reduction
- MeSH
- humans, osteoporosis, hip fractures, calcium, vitamin d, risk, postmenopause, dietary supplements, middle aged, randomized controlled trials as topic
6 autores
- Steven Boonen🇧🇪 · autor de correspondenciaKU Leuven
- Paul T.A.M. Lips🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Roger Bouillon🇧🇪KU Leuven
- Heike Annette Bischoff-Ferrari🇺🇸Brigham and Women's Hospital
- Dirk Vanderschueren🇧🇪KU Leuven
- Patrick Haentjens🇧🇪Vrije Universiteit Brussel
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The purpose of this study was to extend the metaanalysis of Bischoff-Ferrari et al., which found that 700-800 IU/d vitamin D reduced hip fracture risk in elderly individuals by 25%, by defining the need for additional calcium supplementation in individuals receiving vitamin D for the prevention of hip fractures.
Data sources
MEDLINE and EMBASE.com (search terms: "vitamin D" and "hip fracture"), bibliographies of articles retrieved, and the authors' reference files were used as data sources.
Study selection
Selected studies were randomized controlled trials (RCTs) of oral vitamin D with or without calcium supplementation vs. placebo/no treatment in postmenopausal women and/or older men (>or=50 yr) specifically reporting a risk of hip fracture.
Data extraction
Independent extraction was performed by two authors using predefined criteria, including study quality indicators.
Data synthesis
All pooled analyses are based on random-effects models. Based on four RCTs (9083 patients), the pooled relative risk (RR) of hip fracture for vitamin D alone was 1.10 [95% confidence intervals (CI) 0.89, 1.36]. No between-trial heterogeneity was observed. For the six RCTs (45,509 patients) of vitamin D with calcium supplementation, the pooled RR for hip fracture was 0.82 (95% CI 0.71, 0.94). There was no heterogeneity between trials. In an adjusted indirect comparison of the summary RRs from the two metaanalyses, the RR for hip fracture for vitamin D with calcium vs. vitamin D alone was 0.75 (95% CI 0.58, 0.96).
Conclusions
Our analyses, designed to extend the findings of Bischoff-Ferrari et al., suggest that oral vitamin D appears to reduce the risk of hip fractures only when calcium supplementation is added.
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