Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial
Hallahan B, Hibbeln JR, Davis JM, Garland MR
The British journal of psychiatry : the journal of mental science · 107 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Illinois at Urbana-Champaign
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-02-01 · Br J Psychiatry · vol. 190 · número 2 · págs. 118–122
- Editorial
- Cambridge University Press
- Citado
- 191 citas · más que el 99% de estudios similares · 13.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Suicide and Self-Harm Studies · Tryptophan and brain disorders
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, depression, suicidality, psychological well-being, impulsivity, aggression, hostility, dietary fatty acid intake
- MeSH
- humans, recurrence, docosahexaenoic acids, eicosapentaenoic acid, treatment outcome, risk factors, double-blind method, self-injurious behavior, psychiatric status rating scales, dietary supplements, adult, female, male
4 autores
- Brian P. Hallahan🇮🇪Royal College of Surgeons in Ireland; Beaumont Hospital
- Joseph R. Hibbeln🇺🇸National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
- John M. Davis🇺🇸University of Illinois Chicago
- Malcolm R. Garland🇮🇪 · autor de correspondenciaRoyal College of Surgeons in Ireland; Beaumont Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Trials have demonstrated benefits of long-chain omega-3 essential fatty acid (n-3 EFA) supplementation in a variety of psychiatric disorders.
Aims
To assess the efficacy of n-3 EFAs in improving psychological well-being in patients with recurrent self-harm.
Method
Patients (n=49) presenting after an act of repeated self-harm were randomised to receive 1.2 g eicosapentaenoic acid plus 0.9 g decosahexaenoic acid (n=22) or placebo (n=27) for 12 weeks in addition to standard psychiatric care. Six psychological domains were measured at baseline and end point.
Results
At 12 weeks, the n-3 EFA group had significantly greater improvements in scores for depression, suicidality and daily stresses. Scores for impulsivity, aggression and hostility did not differ.
Conclusions
Supplementation achieved substantial reductions in surrogate markers of suicidal behaviour and improvements in well-being. Larger studies are warranted to determine if insufficient dietary intake of n-3 EFAs is a reversible risk factor for self-harm.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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