The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults
Pittas AG, Harris SS, Stark PC, Dawson-Hughes B
Diabetes care · 425 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (K23 DK 61506); National Center for Research Resources (M01 RR-00054); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076092)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2007-03-29 · Diabetes Care · vol. 30 · número 4 · págs. 980–986
- Editorial
- American Diabetes Association
- Citado
- 643 citas · más que el 100% de estudios similares · 26.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Bone health and osteoporosis research
- Palabras clave
- calcium supplementation, vitamin D supplementation, calcium citrate, vitamin D3, blood glucose, fasting blood glucose, insulin resistance, HOMA-IR, impaired fasting glucose, inflammation, C-reactive protein, interleukin-6, older adults, non-diabetic adults
- MeSH
- humans, hyperglycemia, inflammation, body weight, calcium, dietary, insulin, blood glucose, vitamin d, body mass index, reference values, dietary supplements, aged, female, male, biomarkers
4 autores
- Anastassios G. Pittas🇺🇸Tufts Medical Center
- Susan S. Harris🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Paul C. Stark🇺🇸Tufts Medical Center
- Bess Dawson‐Hughes🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years.
Research design and methods
A total of 314 Caucasian adults without diabetes received either 500 mg calcium citrate and 700 IU vitamin D(3) or placebos daily for 3 years in a double-blind, randomized, controlled trial designed for bone-related outcomes. In a post hoc analysis, fasting plasma glucose (FPG), insulin sensitivity (estimated by homeostasis model assessment of insulin resistance [HOMA-IR]), plasma C-reactive protein, and interleukin-6, were measured at baseline and 3 years.
Results
The effects of combined calcium-vitamin D supplementation on 3-year change in FPG depended on baseline FPG (P = 0.02 for interaction). Therefore, we conducted analyses separately in participants with normal fasting glucose (NFG) (FPG <5.6 mmol/l, n = 222) and impaired fasting glucose (IFG) (FPG 5.6-6.9 mmol/l, n = 92) at baseline. Among participants with IFG at baseline, those who took combined calcium-vitamin D supplements had a lower rise in FPG at 3 years compared with those on placebo (0.02 mmol/l [0.4 mg/dl] vs. 0.34 mmol/l [6.1 mg/dl], respectively, P = 0.042) and a lower increase in HOMA-IR (0.05 vs. 0.91, P = 0.031). In the NFG subgroup, there was no difference in the change in FPG or HOMA-IR between the two treatment arms. There were no differences in C-reactive protein or interleukin-6 between the two treatment arms in either subgroup.
Conclusions
In healthy, older adults with IFG, supplementation with calcium and vitamin D may attenuate increases in glycemia and insulin resistance that occur over time. However, our findings should be considered hypothesis generating and need to be confirmed in randomized trials specifically designed for the outcomes of interest.
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