Effects of whey isolate, creatine, and resistance training on muscle hypertrophy
Cribb PJ, Williams AD, Stathis CG, Carey MF, Hayes A
Medicine and science in sports and exercise · 80 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-02-01 · Med Sci Sports Exerc · vol. 39 · número 2 · págs. 298–307
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 165 citas · más que el 96% de estudios similares · 5.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Muscle Physiology and Disorders
- Palabras clave
- whey protein isolate, creatine monohydrate, resistance training, muscle hypertrophy, dietary supplementation, muscle fiber type, cross-sectional area, contractile proteins, muscle strength, body composition, lean body mass, creatine, vastus lateralis, squatting
- MeSH
- muscle, skeletal, humans, creatine, contractile proteins, milk proteins, muscle contraction, weight lifting, dietary supplements, adult, male, muscle fibers, skeletal, whey proteins
5 autores
- Paul J. Cribb🇦🇺Victoria University
- Andrew Dafydd Williams🇦🇺University of Tasmania
- Christos G. Stathis🇦🇺Victoria University
- Michael Carey🇦🇺Victoria University
- Alan Hayes🇦🇺Victoria University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Studies that have attributed gains in lean body mass to dietary supplementation during resistance exercise (RE) training have not reported these changes alongside adaptations at the cellular and subcellular levels. Therefore, the purpose of this study was to examine the effects of two popular supplements--whey protein (WP) and creatine monohydrate (CrM) (both separately and in combination)--on body composition, muscle strength, fiber-specific hypertrophy (i.e., type I, IIa, IIx), and contractile protein accrual during RE training.
Methods
In a double-blind randomized protocol, resistance-trained males were matched for strength and placed into one of four groups: creatine/carbohydrate (CrCHO), creatine/whey protein (CrWP), WP only, or carbohydrate only (CHO) (1.5 g x kg(-1) body weight per day). All assessments were completed the week before and after an 11-wk structured, supervised RE program. Assessments included strength (1RM, three exercises), body composition (DEXA), and vastus lateralis muscle biopsies for determination of muscle fiber type (I, IIa, IIx), cross-sectional area (CSA), contractile protein, and creatine (Cr) content.
Results
Supplementation with CrCHO, WP, and CrWP resulted in significantly greater (P < 0.05) 1RM strength improvements (three of three assessments) and muscle hypertrophy compared with CHO. Up to 76% of the strength improvements in the squat could be attributed to hypertrophy of muscle involved in this exercise. However, the hypertrophy responses within these groups varied at the three levels assessed (i.e., changes in lean mass, fiber-specific hypertrophy, and contractile protein content).
Conclusions
Although WP and/or CrM seem to promote greater strength gains and muscle morphology during RE training, the hypertrophy responses within the groups varied. These differences in skeletal muscle morphology may have important implications for various populations and, therefore, warrant further investigation.
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