A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study
Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP
Journal of the American Geriatrics Society · 247 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (P01AG004390)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2007-01-08 · J Am Geriatr Soc · vol. 55 · número 2 · págs. 234–239
- Editorial
- Wiley
- Citado
- 424 citas · más que el 100% de estudios similares · 30.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Geriatric Care and Nursing Homes
- Palabras clave
- vitamin D supplementation, falls, fall risk, nursing home residents, older adults, long-term care, dose-response relationship, fall prevention
- MeSH
- humans, vitamins, vitamin d, treatment outcome, incidence, proportional hazards models, double-blind method, accidental falls, dose-response relationship, drug, aged, aged, 80 and over, homes for the aged, nursing homes, female, male
6 autores
- Kerry E Broe🇺🇸Boston University; Hebrew SeniorLife
- Tai C. Chen🇺🇸🇨🇭Boston University; Boston Medical Center; Harvard University; University Hospital Zurich; Hebrew SeniorLife
- Janice Weinberg🇺🇸Boston University
- Heike Annette Bischoff-Ferrari🇺🇸🇨🇭Boston University; Boston Medical Center; Harvard University; University Hospital Zurich; Hebrew SeniorLife
- Michael F. Holick🇺🇸🇨🇭Boston University; Boston Medical Center; Harvard University; University Hospital Zurich; Hebrew SeniorLife
- Douglas P. Kiel🇺🇸🇨🇭Boston University; Boston Medical Center; Harvard University; University Hospital Zurich; Hebrew SeniorLife
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents.
Design
Secondary data analysis of a previously conducted randomized clinical trial.
Setting
Seven hundred twenty-five-bed long-term care facility.
Participants
One hundred twenty-four nursing home residents (average age 89).
Intervention
Participants were randomly assigned to receive one of four vitamin D supplement doses (200 IU, 400 IU, 600 IU, or 800 IU) or placebo daily for 5 months.
Measurements
Number of fallers and number of falls assessed using facility incident tracking database.
Results
Over the 5-month study period, the proportion of participants with falls was 44% in the placebo group (11/25), 58% (15/26) in the 200 IU group, 60% (15/25) in the 400 IU group, 60% (15/25) in the 600 IU group, and 20% (5/23) in the 800 IU group. Participants in the 800 IU group had a 72% lower adjusted-incidence rate ratio of falls than those taking placebo over the 5 months (rate ratio=0.28; 95% confidence interval=0.11-0.75). No significant differences were observed for the adjusted fall rates compared to placebo in any of the other supplement groups.
Conclusion
Nursing home residents in the highest vitamin D group (800 IU) had a lower number of fallers and a lower incidence rate of falls over 5 months than those taking lower doses. Adequate vitamin D supplementation in elderly nursing home residents could reduce the number of falls experienced by this high falls risk group.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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