Calcium/vitamin D supplementation and cardiovascular events
Hsia J, Heiss G, Ren H, Allison M, Dolan NC, Greenland P, Heckbert SR, Johnson KC, Manson JE, Sidney S, Trevisan M, Women's Health Initiative Investigators
Circulation · 450 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-02-19 · Circulation · vol. 115 · número 7 · págs. 846–854
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 662 citas · más que el 100% de estudios similares · 30.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Nutritional Studies and Diet
- Palabras clave
- calcium supplementation, vitamin D supplementation, cardiovascular events, coronary artery disease, myocardial infarction, stroke, cerebrovascular disease, postmenopausal women, Women's Health Initiative, vascular calcification
- MeSH
- humans, cerebrovascular disorders, cardiovascular diseases, calcium carbonate, vitamin d, postmenopause, dietary supplements, aged, middle aged, france, female
11 autores
- Judith A. Hsia🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Gerardo M HEISS🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Hong Ren🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Matthew Allison🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Nancy C. Dolan🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Philip Greenland🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Susan R. Heckbert🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Karen Johnson🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- JoAnn E. Manson🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Stephen Sidney🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
- Maurizio Trevisan🇺🇸Northwestern University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Harvard University; University of Tennessee Health Science Center; George Washington University; University of Washington; Kaiser Permanente Oakland Medical Center; University of California San Diego; Fred Hutch Cancer Center; University at Buffalo, State University of New York
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Individuals with vascular or valvular calcification are at increased risk for coronary events, but the relationship between calcium consumption and cardiovascular events is uncertain. We evaluated the risk of coronary and cerebrovascular events in the Women's Health Initiative randomized trial of calcium plus vitamin D supplementation.
Methods and results
We randomized 36,282 postmenopausal women 50 to 79 years of age at 40 clinical sites to calcium carbonate 500 mg with vitamin D 200 IU twice daily or to placebo. Cardiovascular disease was a prespecified secondary efficacy outcome. During 7 years of follow-up, myocardial infarction or coronary heart disease death was confirmed for 499 women assigned to calcium/vitamin D and 475 women assigned to placebo (hazard ratio, 1.04; 95% confidence interval, 0.92 to 1.18). Stroke was confirmed among 362 women assigned to calcium/vitamin D and 377 assigned to placebo (hazard ratio, 0.95; 95% confidence interval, 0.82 to 1.10). In subgroup analyses, women with higher total calcium intake (diet plus supplements) at baseline were not at higher risk for coronary events (P=0.91 for interaction) or stroke (P=0.14 for interaction) if assigned to active calcium/vitamin D.
Conclusions
Calcium/vitamin D supplementation neither increased nor decreased coronary or cerebrovascular risk in generally healthy postmenopausal women over a 7-year use period.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.