Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial
Hass CJ, Collins MA, Juncos JL
Neurorehabilitation and neural repair · 76 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Complementary and Integrative Health
- Gobierno
- NCCIH NIH HHS
- Subvenciones
- National Center for Complementary and Integrative Health (R0-1 AT00612-04); National Center for Complementary and Integrative Health (5 P30 AT000609-04)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2007-02-20 · Neurorehabil Neural Repair · vol. 21 · número 2 · págs. 107–115
- Editorial
- SAGE Publishing
- Citado
- 129 citas · más que el 92% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Parkinson's Disease Mechanisms and Treatments · Nutrition and Health in Aging
- Palabras clave
- Parkinson's disease, resistance training, creatine monohydrate supplementation, upper body strength, muscular endurance, functional performance, sit-to-stand, one-repetition maximum, muscle strength
- MeSH
- humans, parkinson disease, creatine, placebos, treatment outcome, combined modality therapy, exercise therapy, administration, oral, motor activity, body composition, physical endurance, dietary supplements, aged, middle aged, female, male, muscle strength
3 autores
- Chris J. Hass🇺🇸 · autor de correspondenciaColumbia University
- Mitchell A. Collins🇺🇸Kennesaw State University
- Jorge L. Juncos🇺🇸Emory University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Persons with Parkinson disease (PD) exhibit decreased muscular fitness including decreased muscle mass, muscle strength, bioenergetic capabilities and increased fatigability.
Objective
This purpose of this investigation was to evaluate the therapeutic effects of resistance training with and without creatine supplementation in patients with mild to moderate PD.
Methods
Twenty patients with idiopathic PD were randomized to receive creatine monohydrate supplementation plus resistance training (CRE) or placebo (lactose monohydrate) plus resistance training (PLA), using a double-blind procedure. Creatine and placebo supplementation consisted of 20 g/d for the first 5 days and 5 g/d thereafter. Both groups participated in progressive resistance training (24 sessions, 2 times per week, 1 set of 8-12 repetitions, 9 exercises). Participants performed 1-repetition maximum (1-RM) for chest press, leg extension, and biceps curl. Muscular endurance was evaluated for chest press and leg extension as the number of repetitions to failure using 60% of baseline 1-RM. Functional performance was evaluated as the time to perform 3 consecutive chair rises.
Results
Statistical analyses (ANOVA) revealed significant Group x Time interactions for chest press strength and biceps curl strength, and post hoc testing revealed that the improvement was significantly greater for CRE. Chair rise performance significantly improved only for CRE (12%, P=.03). Both PLA and CRE significantly improved 1-RM for leg extension (PLA: 16%; CRE: 18%). Muscular endurance improved significantly for both groups.
Conclusions
These findings demonstrate that creatine supplementation can enhance the benefits of resistance training in patients with PD.
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