Effects of a monounsaturated rapeseed oil and a polyunsaturated sunflower oil diet on lipoprotein levels in humans
Valsta LM, Jauhiainen M, Aro A, Katan MB, Mutanen M
Arteriosclerosis and thrombosis : a journal of vascular biology · 55 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tabriz University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 1992-01-01 · Arterioscler Thromb · vol. 12 · número 1 · págs. 50–57
- Citado
- 118 citas · más que el 99% de estudios similares · 13.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health
- Palabras clave
- rapeseed oil, sunflower oil, high oleic acid, monounsaturated fatty acids, polyunsaturated fatty acids, serum lipoproteins, LDL cholesterol, HDL cholesterol, triglycerides, dietary fat, saturated fat
- MeSH
- humans, helianthus, brassica, cholesterol, dietary fats, unsaturated, fatty acids, monounsaturated, triglycerides, lipoproteins, lipoproteins, hdl, plant oils, apolipoprotein a-i, apolipoproteins b, energy intake, adolescent, adult, middle aged, female, male, cholesterol, ldl, cholesterol, hdl, lipoproteins, hdl2, sunflower oil, rapeseed oil
5 autores
- Liisa M Valsta🇫🇮University of Helsinki
- Matti Jauhiainen🇫🇮University of Helsinki
- A. Aro🇫🇮University of Helsinki
- Mira Katan🇫🇮University of Helsinki
- Marja L. Mutanen🇫🇮University of Helsinki
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effects of high oleic acid rapeseed oil compared with polyunsaturated fats on serum lipoprotein levels are largely unknown. Therefore, we fed 30 women and 29 men a baseline diet rich in saturated fat, which was followed by a diet rich in high oleic and low erucic acid rapeseed oil (total energy content of fat, 38%; saturates, 12.4%; monounsaturates, 16%; n-6 polyunsaturates, 6%; and n-3 polyunsaturates, 2%) and one rich in sunflower oil (total energy content of fat, 38%; saturates, 12.7%; monounsaturates, 10%; n-6 polyunsaturates, 13%; and n-3 polyunsaturates, 0%). The oils were incorporated into mixed natural diets that were dispensed in a random order for 3.5 weeks each in a blinded crossover design. The diet composition was confirmed by analysis of duplicate diets. Both test diets reduced serum total cholesterol (TC) and low density lipoprotein (LDL) cholesterol levels from baseline, the monounsaturated rapeseed oil diet more than the polyunsaturated sunflower oil diet (TC: -15% versus -12%, p less than 0.01; LDL cholesterol: -23% versus -17%, p less than 0.01). Very low density lipoprotein (VLDL) cholesterol and total, VLDL, and LDL triglyceride levels were lower during the sunflower oil diet compared with the rapeseed oil diet. Total high density lipoprotein (HDL) cholesterol levels remained unchanged by both diets. The consumption of rapeseed oil resulted in a more favorable HDL2 to LDL cholesterol ratio (0.43 +/- 0.19 versus 0.39 +/- 0.18, p less than 0.01) and an apolipoprotein A-I to B ratio (3.0 +/- 1.4 versus 2.4 +/- 1.6, p less than 0.001) than did the sunflower oil.(ABSTRACT TRUNCATED AT 250 WORDS)
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