Oral magnesium and the prevention of preterm labor in a high-risk group of patients
Martin RW, Perry KG, Hess LW, Martin JN, Morrison JC
American journal of obstetrics and gynecology · 17 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1992-01-01 · Am J Obstet Gynecol · vol. 166 · número 1 · págs. 144–147
- Editorial
- Elsevier BV
- Citado
- 26 citas · más que el 76% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 18 trabajos
- Acceso
- De pago
- Áreas de investigación
- Preterm Birth and Chorioamnionitis · Magnesium in Health and Disease · Pregnancy and preeclampsia studies
- Palabras clave
- preterm labor, preterm birth prevention, high-risk pregnancy, serum magnesium, uterine activity monitoring, birth weight, gestational age
- MeSH
- humans, birth weight, magnesium, gluconates, administration, oral, gestational age, pregnancy, uterine contraction, female, obstetric labor, premature
5 autores
- Rick W. Martin🇺🇸 · autor de correspondenciaUniversity of Mississippi Medical Center
- Kenneth G. Perry
- L. Wayne Hess
- James Nello Martin Jr.
- John C. Morrison
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The null hypothesis of this study is that treatment with oral magnesium gluconate 1 gm four times daily will not decrease the rate of preterm labor and delivery in a high-risk group of pregnant women.
Study design
Fifty-four women at risk for preterm delivery were selected randomly to receive magnesium gluconate 1 gm orally four times daily or placebo. These women were monitored prospectively for signs and symptoms of preterm labor. A subgroup of 31 women also received a home uterine activity monitor. The serum magnesium level was measured initially and again 2 weeks after study enrollment. The data were analyzed with Fisher's exact test and analysis of variance.
Results
Preterm labor developed in 15 women in the placebo group and in 16 women in the magnesium group. There were no differences in birth weight or gestational age at delivery. The mean increase in serum magnesium level while the patients were taking magnesium gluconate was 0.10 mg/dl (p = not significant). Five women did not have an increase in serum magnesium level and preterm labor developed in all of them.
Conclusion
Magnesium gluconate in a dose of 1 gm four times daily is not effective for preventing preterm delivery in a high-risk group of patients.
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