A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain
Goldberg RJ, Katz J
Pain · 298 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- York University
- Gobierno
- Canada Research Chairs
- Gobierno
- Canadian Institutes of Health Research
Según 3 financiadores declarados.
Publicación
- Publicado
- 2007-03-02 · Pain · vol. 129 · número 1 · págs. 210–223
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 525 citas · más que el 93% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Inflammatory mediators and NSAID effects · Rheumatoid Arthritis Research and Therapies
- Palabras clave
- omega-3 polyunsaturated fatty acids, dietary supplementation, joint pain, rheumatoid arthritis, inflammatory bowel disease, dysmenorrhea, morning stiffness, NSAID use, adjunctive therapy, complementary and alternative medicine
- MeSH
- humans, arthralgia, inflammation, fatty acids, omega-3, central nervous system stimulants, pain measurement, chi-square distribution, reproducibility of results, dose-response relationship, drug, dietary supplements, evaluation studies as topic, randomized controlled trials as topic
2 autores
- Robert J. Goldberg🇨🇦York University
- Joel D Katz🇨🇦 · autor de correspondenciaYork University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Between 40% and 60% of Americans use complementary and alternative medicine to manage medical conditions, prevent disease, and promote health and well-being. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been used to treat joint pain associated with several inflammatory conditions. We conducted a meta-analysis of 17 randomized, controlled trials assessing the pain relieving effects of omega-3 PUFAs in patients with rheumatoid arthritis or joint pain secondary to inflammatory bowel disease and dysmenorrhea. Meta-analysis was conducted with Cochrane Review Manager 4.2.8. for six separate outcomes using standardized mean differences (SMDs) as a measure of effect size: (1) patient assessed pain, (2) physician assessed pain, (3) duration of morning stiffness, (4) number of painful and/or tender joints, (5) Ritchie articular index, and (6) nonselective nonsteroidal anti-inflammatory drug consumption. Supplementation with omega-3 PUFAs for 3-4 months reduces patient reported joint pain intensity (SMD: -0.26; 95% CI: -0.49 to -0.03, p=0.03), minutes of morning stiffness (SMD: -0.43; 95% CI: -0.72 to -0.15, p=0.003), number of painful and/or tender joints (SMD: -0.29; 95% CI: -0.48 to -0.10, p=0.003), and NSAID consumption (SMD: -0.40; 95% CI: -0.72 to -0.08, p=0.01). Significant effects were not detected for physician assessed pain (SMD: -0.14; 95% CI: -0.49 to 0.22, p=0.45) or Ritchie articular index (SMD: 0.15; 95% CI: -0.19 to 0.49, p=0.40) at 3-4 months. The results suggest that omega-3 PUFAs are an attractive adjunctive treatment for joint pain associated with rheumatoid arthritis, inflammatory bowel disease, and dysmenorrhea.
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