Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men
Liou YA, King DJ, Zibrik D, Innis SM
The Journal of nutrition · 150 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Molly Towell Perinatal Research Foundation
- Organización sin fines de lucro
- Canadian Foundation for Dietetic Research
- Gobierno
- Michael Smith Health Research BC
Según 3 financiadores declarados.
Publicación
- Publicado
- 2007-04-01 · J Nutr · vol. 137 · número 4 · págs. 945–952
- Editorial
- Elsevier BV
- Citado
- 231 citas · más que el 99% de estudios similares · 16.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Lipid metabolism and biosynthesis
- Palabras clave
- linoleic acid, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, plasma phospholipid fatty acids, dietary fat composition, vegetable oil replacement, omega-3 fatty acid metabolism, n-6/n-3 ratio, platelet aggregation, inflammatory markers, healthy men
- MeSH
- humans, inflammation, lipids, dietary fats, alpha-linolenic acid, eicosapentaenoic acid, fatty acids, arachidonic acid, linoleic acid, phospholipids, diet, cross-over studies, platelet aggregation, dose-response relationship, drug, adult, male, biomarkers
4 autores
- Yi-Fan Liou🇨🇦University of British Columbia; Child and Family Research Institute
- D. Janette King🇨🇦University of British Columbia; Child and Family Research Institute
- Deborah Zibrik🇨🇦University of British Columbia; Child and Family Research Institute
- Sheila Margaret Innis🇨🇦 · autor de correspondenciaUniversity of British Columbia; Child and Family Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
High linoleic acid (LA) intakes have been suggested to reduce alpha-linolenic acid [ALA, 18:3(n-3)] metabolism to eicosapentaenoic acid [EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)], and favor high arachidonic acid [ARA, 20:4(n-6)]. We used a randomized cross-over study with men (n = 22) to compare the effect of replacing vegetable oils high in LA with oils low in LA in foods, while maintaining constant ALA, for 4 wk each, on plasma (n-3) fatty acids. Nonvegetable sources of fat, except fish and seafoods, were unrestricted. We determined plasma phospholipid fatty acids at wk 0, 2, 4, 6, and 8, and triglycerides, cholesterol, serum CRP, and IL-6, and platelet aggregation at wk 0, 4, and 8. LA and ALA intakes were 3.8 +/- 0.12% and 1.0 +/- 0.05%, and 10.5 +/- 0.53% and 1.1 +/- 0.06% energy with LA:ALA ratios of 4:0 and 10:1 during the low and high LA diets, respectively. The plasma phospholipid LA was higher and EPA was lower during the high than during the low LA diet period (P < 0.001), but DHA declined over the 8-wk period (r = -0.425, P < 0.001). The plasma phospholipid ARA:EPA ratios were (mean +/- SEM) 20.7 +/- 1.52 and 12.9 +/- 1.01 after 4 wk consuming the high or low LA diets, respectively (P < 0.001); LA was inversely associated with EPA (r = -0.729, P < 0.001) but positively associated with ARA:EPA (r = 0.432, P < 0.001). LA intake did not influence ALA, ARA, DPA, DHA, or total, LDL or HDL cholesterol, CRP or IL-6, or platelet aggregation. In conclusion, high LA intakes decrease plasma phospholipid EPA and increase the ARA:EPA ratio, but do not favor higher ARA.
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