The effects of high walnut and cashew nut diets on the antioxidant status of subjects with metabolic syndrome
Davis L, Stonehouse W, Loots du T, Mukuddem-Petersen J, van der Westhuizen FH, Hanekom SM, Jerling JC
European journal of nutrition · 67 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-03-21 · Eur J Nutr · vol. 46 · número 3 · págs. 155–164
- Editorial
- Springer Science+Business Media
- Citado
- 121 citas · más que el 96% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Phytochemicals and Antioxidant Activities · Nutritional Studies and Diet
- Palabras clave
- Juglans regia, Anacardium occidentale, metabolic syndrome, antioxidant status, prudent diet, ORAC, glutathione, glutathione disulfide, total oxidant status, nut consumption, dietary intervention
- MeSH
- humans, anacardium, juglans, reactive oxygen species, insulin, blood glucose, glutathione, glutathione disulfide, antioxidants, oxidation-reduction, middle aged, female, male, lipid metabolism, metabolic syndrome
7 autores
- Lisa Davis🇿🇦 · autor de correspondenciaNorth-West University
- Welma Stonehouse🇿🇦🇳🇿North-West University; Massey University
- Du Toit Loots🇿🇦North-West University
- Janine Mukuddem-Petersen🇿🇦North-West University
- Francois Hendrikus van der Westhuizen🇿🇦North-West University
- Susanna Magrietha Hanekom🇿🇦North-West University
- Johann C. Jerling🇿🇦North-West University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nut consumption is associated with a protective effect against coronary heart disease, partly due to its high antioxidant content. It is hypothesized that the inclusion of nuts in the diet will improve the antioxidant status of subjects with metabolic syndrome who may be vulnerable to impaired antioxidant status.
Aim
The effects of high cashew nut and high walnut diets on the antioxidant status of subjects with metabolic syndrome are investigated.
Methodology
Sixty-four volunteers (29 male and 35 female, 45 +/- 10y) with metabolic syndrome (diagnosed by using the ATP III criteria) received a prudent control diet, prepared in the metabolic kitchen of the North-West University, Potchefstroom campus (NWU-PC) for a period of 3 weeks (run-in). The participants were grouped according to gender and age and randomized into three groups, receiving either the walnut, cashew nut or the control diets for 8 weeks, while maintaining a stable body weight. Nuts provided 20% of daily energy intake. Fasting blood samples were taken after the run-in period (baseline) and at the end of the intervention period and analyzed for various antioxidant capacity markers.
Results
The oxygen radical absorbance capacity (ORAC) of the walnut and cashew nut diets were significantly higher than the control diet. Despite this, the walnut and cashew nut diets had no significant effects on serum ORAC, reduced (GSH), oxidized (GSSG) glutathione, GSH:GSSG or diacron reactive metabolites (dRom) (total oxidant status) levels compared to the control group. However, all three groups showed significant improvements in antioxidant status from baseline to end (GSSG and dRom levels decreased; GSG:GSSG ratio and ORAC levels increased). This may be due to a general increased antioxidant intake from the prudent diet compared to the habitual diets.
Conclusion
Although the inclusion of walnuts and cashew nuts into a prudent diet resulted in an increased antioxidant capacity (ORAC) of the nut diets, compared to the control diet, it did not improve the serum antioxidant profiles of subjects with metabolic syndrome.
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