Financiado en parte por AstraZeneca, AstraZeneca Australia, Allergopharma
Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years
Almqvist C, Garden F, Xuan W, Mihrshahi S, Leeder SR, Oddy W, Webb K, Marks GB, CAPS team
The Journal of allergy and clinical immunology · 90 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- AstraZeneca
- Empresa
- AstraZeneca Australia
- Organización sin fines de lucro
- Svenska Läkaresällskapet
- Empresa
- Allergopharma
- Gobierno
- Medical Research Council
- Gobierno
- National Health and Medical Research Council
Según 6 financiadores declarados.
Publicación
- Publicado
- 2007-03-27 · J Allergy Clin Immunol · vol. 119 · número 6 · págs. 1438–1444
- Editorial
- Elsevier BV
- Citado
- 144 citas · más que el 99% de estudios similares · 12.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 19 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Asthma and respiratory diseases · Food Allergy and Anaphylaxis Research
- Palabras clave
- omega-3 fatty acids, omega-6 fatty acids, polyunsaturated fatty acids, atopy, asthma, wheezing, atopic dermatitis, dietary fatty acid supplementation, plasma fatty acids, dietary fatty acid intake, supplement compliance, early childhood, family history of asthma
- MeSH
- humans, asthma, hypersensitivity, immediate, fatty acids, omega-3, fatty acids, omega-6, treatment outcome, cohort studies, dietary supplements, child, preschool, infant
8 autores
- Catarina Almqvist🇦🇺🇸🇪 · autor de correspondenciaThe University of Sydney; Woolcock Institute of Medical Research; Karolinska Institutet
- Frances L. Garden🇦🇺New South Wales Department of Health
- Wei Xuan🇦🇺Woolcock Institute of Medical Research
- Seema Mihrshahi🇦🇺Children's Hospital at Westmead
- Steve Leeder🇦🇺The University of Sydney
- Wendy Hazel Oddy🇦🇺The Kids Research Institute Australia; Curtin University
- Karen Webb🇦🇺The University of Sydney
- Guy Barrington Marks🇦🇺🇸🇪The University of Sydney; Woolcock Institute of Medical Research; Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The Childhood Asthma Prevention Study was a randomized controlled trial conducted in children with a family history of asthma in whom omega-3 fatty acid supplementation and restriction of dietary omega-6 fatty acids did not prevent asthma, eczema, or atopy at age 5 years.
Objective
We sought to examine the relation of all measures of omega-3 and omega-6 polyunsaturated fatty acids with outcomes at age 5 years in the whole birth cohort, regardless of randomization group.
Methods
Plasma fatty acids were measured at 18 months, 3 years, and 5 years. Compliance with the fatty acid supplements was estimated every 6 months. Dietary intake was assessed at 18 months by means of weighed-food record and at 3 years by means of food-frequency questionnaire. At age 5 years, 516 children were examined for wheeze and eczema (questionnaire) and atopy (skin prick tests, n = 488). Multiple logistic regression was used to evaluate associations between exposures and outcomes.
Results
Plasma levels of omega-3 or omega-6 fatty acids were not associated with wheeze, eczema, or atopy at age 5 years (P = .11-.96). Overall, fatty acid exposure, measured as plasma levels, dietary intake, and compliance with supplements, was not associated with any respiratory or allergic outcomes (P = .35-.59).
Conclusion
This observational analysis of the cohort, using the full range of observed variation in omega-3 and omega-6 fatty acid exposure, supports the negative findings of the randomized controlled trial.
Clinical implications
Modification of dietary polyunsaturated fatty acids in early childhood is not helpful in preventing atopy and asthma.
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