The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
Pittas AG, Lau J, Hu FB, Dawson-Hughes B
The Journal of clinical endocrinology and metabolism · 1,277 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (K23 DK 61506); National Institute of Diabetes and Digestive and Kidney Diseases (K23 DK061506); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076092); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK76092); National Institute on Aging (U01 AG010353)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2007-03-27 · J Clin Endocrinol Metab · vol. 92 · número 6 · págs. 2017–2029
- Editorial
- Oxford University Press
- Citado
- 2,001 citas · más que el 99% de estudios similares · 8.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 128 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Bone health and osteoporosis research
- Palabras clave
- vitamin D, calcium, type 2 diabetes, 25-hydroxyvitamin D, dairy consumption, metabolic syndrome, vitamin D supplementation, calcium supplementation, glucose homeostasis, diabetes prevention, impaired glucose tolerance
- MeSH
- animals, humans, diabetes mellitus, type 2, vitamin d deficiency, calcium, vitamin d, prevalence
4 autores
- Anastassios G. Pittas🇺🇸 · autor de correspondenciaTufts Medical Center
- Joseph Lau🇺🇸Tufts Medical Center
- Frank B. Hu🇺🇸Harvard University
- Bess Dawson‐Hughes🇺🇸Tufts University; Tufts Medical Center; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Altered vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes mellitus (type 2 DM). EVIDENCE ACQUISITION AND ANALYSES: MEDLINE review was conducted through January 2007 for observational studies and clinical trials in adults with outcomes related to glucose homeostasis. When data were available to combine, meta-analyses were performed, and summary odds ratios (OR) are presented.
Evidence synthesis
Observational studies show a relatively consistent association between low vitamin D status, calcium or dairy intake, and prevalent type 2 DM or metabolic syndrome [OR (95% confidence interval): type 2 DM prevalence, 0.36 (0.16-0.80) among nonblacks for highest vs. lowest 25-hydroxyvitamin D; metabolic syndrome prevalence, 0.71 (0.57-0.89) for highest vs. lowest dairy intake]. There are also inverse associations with incident type 2 DM or metabolic syndrome [OR (95% confidence interval): type 2 DM incidence, 0.82 (0.72-0.93) for highest vs. lowest combined vitamin D and calcium intake; 0.86 (0.79-0.93) for highest vs. lowest dairy intake]. Evidence from trials with vitamin D and/or calcium supplementation suggests that combined vitamin D and calcium supplementation may have a role in the prevention of type 2 DM only in populations at high risk (i.e. glucose intolerance). The available evidence is limited because most observational studies are cross-sectional and did not adjust for important confounders, whereas intervention studies were short in duration, included few subjects, used a variety of formulations of vitamin D and calcium, or did post hoc analyses.
Conclusions
Vitamin D and calcium insufficiency may negatively influence glycemia, whereas combined supplementation with both nutrients may be beneficial in optimizing glucose metabolism.
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