Maternal caffeine consumption and risk of cardiovascular malformations
Browne ML, Bell EM, Druschel CM, Gensburg LJ, Mitchell AA, Lin AE, Romitti PA, Correa A, National Birth Defects Prevention Study
Birth defects research. Part A, Clinical and molecular teratology · 39 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Public Health Service
- Gobierno
- PHS HHS
- Subvenciones
- U.S. Public Health Service (U50/CCU0223184)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2007-04-02 · Birth Defects Res A Clin Mol Teratol · vol. 79 · número 7 · págs. 533–543
- Citado
- 60 citas · más que el 93% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago · PUBLIC-DOMAIN
- Áreas de investigación
- Coffee research and impacts · Prenatal Substance Exposure Effects · Congenital Heart Disease Studies
- Palabras clave
- maternal caffeine consumption, cardiovascular anomalies, congenital malformations, teratogenicity, tetralogy of Fallot, atrial septal defect, coffee consumption, effect modification, maternal smoking
- MeSH
- humans, cardiovascular abnormalities, caffeine, central nervous system stimulants, risk assessment, case-control studies, pregnancy, adolescent, adult, child, infant, newborn, united states, female
8 autores
- Marilyn L. Browne🇺🇸 · autor de correspondenciaNew York State Department of Health
- Erin M. Bell🇺🇸University at Albany, State University of New York
- Charlotte M. Druschel🇺🇸New York State Department of Health
- Lenore J. Gensburg🇺🇸New York State Department of Health
- Allen A. Mitchell🇺🇸Boston University
- Angela E. Lin🇺🇸Massachusetts General Hospital
- Paul A. Romitti🇺🇸University of Iowa
- Adolfo Correa🇺🇸Centers for Disease Control and Prevention; National Center on Birth Defects and Developmental Disabilities
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The physiologic effects and common use of caffeine during pregnancy call for examination of maternal caffeine consumption and risk of birth defects. Epidemiologic studies have yielded mixed results, but such studies have grouped etiologically different defects and have not evaluated effect modification.
Methods
The large sample size and precise case classification of the National Birth Defects Prevention Study allowed us to examine caffeine consumption and specific cardiovascular malformation (CVM) case groups. We studied consumption of caffeinated coffee, tea, soda, and chocolate to estimate total caffeine intake and separately examined exposure to each caffeinated beverage. Smoking, alcohol, vasoactive medications, folic acid supplement use, and infant gender were evaluated for effect modification. Maternal interview reports for 4,196 CVM case infants overall and 3,957 control infants were analyzed.
Results
We did not identify any significant positive associations between maternal caffeine consumption and CVMs. For tetralogy of Fallot, nonsignificant elevations in risk were observed for moderate (but not high) caffeine intake overall and among nonsmokers (ORs of 1.3 to 1.5). Risk estimates for both smoking and consuming caffeine were less than the sum of the excess risks for each exposure. We observed an inverse trend between coffee intake and risk of atrial septal defect; however, this single significant pattern of association might have been a chance finding.
Conclusions
Our study found no evidence for an appreciable teratogenic effect of caffeine with regard to CVMs.
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