The association between soy nut consumption and decreased menopausal symptoms
Welty FK, Lee KS, Lew NS, Nasca MM, Zhou JR
Journal of women's health (2002) · 26 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK 040561); National Institute of Diabetes and Digestive and Kidney Diseases (K07 DK002974); National Center for Research Resources (RR 01032); National Heart, Lung, and Blood Institute (R01 HL056895)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2007-04-01 · J Womens Health (Larchmt) · vol. 16 · número 3 · págs. 361–369
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 39 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Phytoestrogen effects and research · Menopause: Health Impacts and Treatments · Estrogen and related hormone effects
- Palabras clave
- hot flashes, menopausal symptoms, postmenopausal women, isoflavones, soy protein, vasomotor symptoms, psychosocial symptoms, sexual symptoms, dietary protein substitution, physical activity
- MeSH
- humans, nuts, hot flashes, isoflavones, soybean proteins, treatment outcome, phytotherapy, cross-over studies, menopause, reference values, quality of life, middle aged, women's health, female, glycine max
5 autores
- Francine K. Welty🇺🇸Beth Israel Deaconess Medical Center; Harvard University
- Karen S. Lee🇺🇸Beth Israel Deaconess Medical Center
- Natalie S. Lew🇺🇸Beth Israel Deaconess Medical Center
- Melita M. Nasca🇺🇸Beth Israel Deaconess Medical Center
- Jin‐Rong Zhou🇺🇸Beth Israel Deaconess Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological studies suggest a low incidence of hot flashes in populations that consume dietary soy. The present study examined the effect of soy nuts on hot flashes and menopausal symptoms.
Methods
Sixty healthy postmenopausal women were randomized in a crossover design to a therapeutic lifestyle changes (TLC) diet alone and a TLC diet of similar energy, fat, and protein content in which one-half cup soy nuts divided into three or four portions spaced throughout the day (containing 25 g soy protein and 101 mg aglycone isoflavones) replaced 25 g of nonsoy protein. During each 8-week diet period, subjects recorded the number of hot flashes and amount of exercise daily. At the end of each 8-week diet period, subjects filled out the menopausal symptom quality of life questionnaire.
Results
Compared to the TLC diet alone, the TLC diet plus soy nuts was associated with a 45% decrease in hot flashes (7.5 +/- 3.6 vs. 4.1 +/- 2.6 hot flashes day, respectively, p 4.5 hot flashes/day at baseline and 41% in those with <or=4.5 hot flashes/day (2.2 +/- 1.2 vs. 1.3 +/- 1.1, respectively, p < 0.001). Soy nut intake was also associated with significant improvement in scores on the menopausal symptom quality of life questionnaire: 19% decrease in vasomotor score (p = 0.004), 12.9% reduction in psychosocial score (p = 0.01), 9.7% decrease in physical score (p = 0.045), and a trend toward improvement in the sexual score, with a 17.7% reduction in symptoms (p = 0.129). The amount of exercise had no effect on hot flash reduction.
Conclusions
Substituting soy nuts for nonsoy protein in a TLC diet and consumed three or four times throughout the day is associated with a decrease in hot flashes and improvement in menopausal symptoms.
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