Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial
Chung YL, Alexanderson H, Pipitone N, Morrison C, Dastmalchi M, Ståhl-Hallengren C, Richards S, Thomas EL, Hamilton G, Bell JD, Lundberg IE, Scott DL
Arthritis and rheumatism · 85 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-04-30 · Arthritis Rheum · vol. 57 · número 4 · págs. 694–702
- Editorial
- Wiley
- Citado
- 145 citas · más que el 97% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Inflammatory Myopathies and Dermatomyositis · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- creatine supplementation, idiopathic inflammatory myopathies, polymyositis, dermatomyositis, muscle weakness, home exercise program, functional performance, muscle energy metabolism, phosphocreatine, endurance
- MeSH
- humans, muscle weakness, myositis, phosphorus isotopes, creatine, phosphocreatine, placebos, treatment outcome, exercise, magnetic resonance spectroscopy, administration, oral, double-blind method, energy metabolism, middle aged, female, male, muscle strength
12 autores
- Yuen‐Li Chung🇬🇧King's College London; Hammersmith Hospital; Imperial College London
- Helene Alexanderson🇸🇪Karolinska University Hospital
- Nicolò Pipitone🇬🇧King's College London
- Catherine Morrison🇬🇧King's College London
- Maryam Dastmalchi
- C. Stahl-Hallengren🇸🇪Karolinska University Hospital; Karolinska Institutet
- Selwyn Richards🇬🇧King's College London
- Elizabeth Louise Thomas🇬🇧Hammersmith Hospital; Imperial College London
- Gavin Hamilton🇬🇧Hammersmith Hospital; Imperial College London
- Jimmy David Bell🇬🇧Hammersmith Hospital; Imperial College London
- Ingrid E. Lundberg🇸🇪Karolinska University Hospital; Karolinska Institutet
- David Lloyd Scott🇬🇧King's College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To test the hypothesis that oral creatine supplements with exercise are more effective than exercise alone in improving muscle function in patients with established dermatomyositis or polymyositis receiving chronic medical therapies who are clinically weak yet stable.
Methods
In a 6-month, 2-center, double-blind, randomized controlled trial, patients were randomized to receive oral creatine supplements (8 days, 20 gm/day then 3 gm/day) or placebo. All patients followed a home exercise program. The primary outcome was aggregate functional performance time (AFPT), reflecting the ability to undertake high-intensity exercise. Secondary outcomes included a functional index measuring endurance and muscle bioenergetics on (31)P magnetic resonance spectroscopy ((31)P MRS). Patients were receiving stable immunosuppressive treatment and/or corticosteroids.
Results
A total of 37 patients with polymyositis or dermatomyositis were randomized (19 to creatine, 18 to placebo); 29 completed 6 months. Intent-to-treat analyses demonstrated that AFPT improved significantly at 6 months with creatine (median decrease 13%, range -32-8%) compared with placebo (median decrease 3%, range -13-16%; P = 0.029 by Mann-Whitney U test). A completer analysis also showed significant benefits from creatine (P = 0.014). The functional index improved significantly with both creatine and placebo (P < 0.05 by paired Wilcoxon's rank sum test), with a significant benefit between groups in the completer analysis only. Phosphocreatine/beta-nucleoside triphosphate ratios using MRS increased significantly in the creatine group (P < 0.05) but not in the control group. No clinically relevant adverse events were associated with creatine.
Conclusion
Oral creatine supplements combined with home exercises improve functional performance without significant adverse effects in patients with polymyositis or dermatomyositis. They appear safe, effective, and inexpensive.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.