Effects of fish-oil supplementation on myocardial fatty acids in humans
Metcalf RG, James MJ, Gibson RA, Edwards JR, Stubberfield J, Stuklis R, Roberts-Thomson K, Young GD, Cleland LG
The American journal of clinical nutrition · 160 citas
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Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-05-01 · Am J Clin Nutr · vol. 85 · número 5 · págs. 1222–1228
- Editorial
- Elsevier BV
- Citado
- 217 citas · más que el 99% de estudios similares · 11.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Edible Oils Quality and Analysis
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, myocardial phospholipids, linseed oil, olive oil, cardiopulmonary bypass, right atrial appendage, cardiomyocytes
- MeSH
- myocardium, humans, cardiovascular diseases, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, linseed oil, membrane lipids, phospholipids, fish oils, plant oils, cardiopulmonary bypass, risk factors, dietary supplements, aged, middle aged, female, male, olive oil
9 autores
- Robert G. Metcalf🇦🇺 · autor de correspondenciaRoyal Adelaide Hospital; Hanson Institute; The University of Adelaide
- Michael J. James🇦🇺Royal Adelaide Hospital; Hanson Institute; The University of Adelaide
- Robert Alan Gibson🇦🇺Royal Adelaide Hospital; Hanson Institute; The University of Adelaide
- James R. M. Edwards🇦🇺Royal Adelaide Hospital; Hanson Institute; The University of Adelaide
- John Stubberfield🇦🇺Royal Adelaide Hospital; Hanson Institute; The University of Adelaide
- Robert G Stuklis🇦🇺Royal Adelaide Hospital; Hanson Institute; The University of Adelaide
- Kurt C. Roberts‐Thomson🇦🇺Royal Adelaide Hospital; Hanson Institute; The University of Adelaide
- Glenn D. Young🇦🇺Royal Adelaide Hospital; Hanson Institute; The University of Adelaide
- Leslie G. Cleland🇦🇺Royal Adelaide Hospital; Hanson Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Increased fish or fish-oil consumption is associated with reduced risk of cardiac mortality, especially sudden death. This benefit putatively arises from the incorporation of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cardiomyocyte phospholipids.
Objective
The study examined the kinetics of incorporation of n-3 fatty acids into human myocardial membrane phospholipids during supplementation with fish oil and alpha-linolenic acid-rich flaxseed oil.
Design
Patients with low self-reported fish intake (<1 fish meal/wk and no oil supplements) accepted for elective cardiac surgery involving cardiopulmonary bypass were randomly allocated to 1 of 6 groups: no supplement; fish oil (6 g EPA+DHA/d) for either 7, 14, or 21 d before surgery; flaxseed oil; or olive oil (both 10 mL/d for 21 d before surgery). Right atrial appendage tissue removed during surgery and blood collected at enrollment and before surgery were analyzed for phospholipid fatty acids.
Results
Surgery rescheduling resulted in a range of treatment times from 7 to 118 d. In the fish-oil-treated subjects, accumulation of EPA and DHA in the right atrium was curvilinear with time and reached a maximum at approximately 30 d of treatment and displaced mainly arachidonic acid. Flaxseed oil supplementation yielded a small increase in atrial EPA but not DHA, whereas olive oil did not significantly change atrial n-3 fatty acids.
Conclusion
The results of the present study show that dietary n-3 fatty acids are rapidly incorporated into human myocardial phospholipids at the expense of arachidonic acid during high-dose fish-oil supplementation.
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