Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial
Krauss-Etschmann S, Shadid R, Campoy C, Hoster E, Demmelmair H, Jiménez M, Gil A, Rivero M, Veszprémi B, Decsi T, Koletzko BV, Nutrition and Health Lifestyle (NUHEAL) Study Group
The American journal of clinical nutrition · 126 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-05-01 · Am J Clin Nutr · vol. 85 · número 5 · págs. 1392–1400
- Editorial
- Elsevier BV
- Citado
- 209 citas · más que el 99% de estudios similares · 14.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Aquaculture Nutrition and Growth
- Palabras clave
- fish oil supplementation, folic acid supplementation, methyltetrahydrofolate, docosahexaenoic acid, eicosapentaenoic acid, n-3 long-chain polyunsaturated fatty acids, pregnancy, fetal development, pregnancy outcomes, maternal micronutrient status
- MeSH
- fetal blood, humans, folic acid, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fish oils, vitamin b complex, pregnancy outcome, analysis of variance, double-blind method, fetal development, pregnancy, maternal-fetal exchange, pregnancy trimester, second, pregnancy trimester, third, dietary supplements, adolescent, adult, female, maternal nutritional physiological phenomena
11 autores
- Susanne Krauss‐Etschmann🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Rania Shadid🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Cristina Campoy🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Eva Hoster🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Hans Demmelmair🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Margarita Jiménez🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Ángel Gil🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Montserrat Rivero🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Béla Veszprémi🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Támas Décsi🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
- Berthold Viktor Koletzko🇪🇸🇩🇪🇭🇺Universidad de Granada; Helmholtz Munich; Ordesa (Spain); University of Pecs; Ludwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Pregnant women usually meet their increased energy needs but do not always meet their increased micronutrient requirements. The supply of both folic acid and docosahexaenoic acid (DHA) has been related to positive pregnancy and infant outcomes.
Objective
We aimed to assess whether fish-oil (FO) supplementation with or without folate from gestation week 22 to birth improves maternal and fetal n-3 long-chain polyunsaturated fatty acid (n-3 LC-PUFA) status.
Design
We conducted a multicenter (Germany, Hungary, and Spain), randomized, double-blind, 2 x 2 factorial, placebo-controlled trial. From gestation week 22 until delivery, 311 pregnant women received daily a preparation with FO [0.5 g DHA and 0.15 g eicosapentaenoic acid (EPA)], 400 microg methyltetrahydrofolic acid (MTHF), FO with MTHF, or placebo. Outcome measures included maternal and cord plasma DHA and EPA contents at gestation weeks 20 and 30 and at delivery, indicators of pregnancy outcome, and fetal development.
Results
FO significantly (P<0.001) increased maternal DHA and EPA (% by wt), as shown by 3-factor repeated-measures ANOVA (ie, MTHF, FO, and time) with adjustment for maternal baseline DHA and EPA. In addition, FO significantly (P<0.001) increased cord blood DHA (% by wt; 2-factor ANOVA). MTHF was significantly (P=0.046) associated with increased maternal DHA (% by wt). There was no FO x MTHF interaction for the time course of DHA or EPA (P=0.927 and 0.893). Pregnancy outcomes and fetal development did not differ significantly among the intervention groups.
Conclusions
FO supplementation from gestation week 22 until delivery improves fetal n-3 LC-PUFA status and attenuates depletion of maternal stores. MTHF may further enhance maternal n-3 LC-PUFA proportions.
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