Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects
Andersson A, Tengblad S, Karlström B, Kamal-Eldin A, Landberg R, Basu S, Aman P, Vessby B
The Journal of nutrition · 150 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- VINNOVA
- Gobierno
- Svenska Forskningsrådet Formas
- Gobierno
- Vetenskapsrådet
Según 3 financiadores declarados.
Publicación
- Publicado
- 2007-06-01 · J Nutr · vol. 137 · número 6 · págs. 1401–1407
- Editorial
- Elsevier BV
- Citado
- 223 citas · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Phytochemicals and Antioxidant Activities
- Palabras clave
- whole grains, refined grains, insulin sensitivity, lipid peroxidation, inflammation, 8-isoprostane, C-reactive protein, interleukin-6, overweight adults, dietary intervention, blood pressure, serum lipids
- MeSH
- humans, inflammation, insulin, lipids, dinoprost, interleukin-6, body mass index, diet, cross-over studies, blood pressure, adult, aged, middle aged, female, male, overweight, edible grain
8 autores
- Agneta Andersson🇸🇪 · autor de correspondenciaUppsala University
- Siv Tengblad🇸🇪Uppsala University
- Brita Karlström🇸🇪Uppsala University
- Afaf Kamal‐Eldin🇸🇪Swedish University of Agricultural Sciences
- Rikard Landberg🇸🇪Swedish University of Agricultural Sciences
- Samar Basu🇸🇪Uppsala University
- Per Åman🇸🇪Swedish University of Agricultural Sciences
- Bengt OH Vessby🇸🇪Uppsala University
Resumen
El texto original del estudio, en el idioma en que se publicó.
High intakes of whole grain foods are inversely related to the incidence of coronary heart diseases and type 2 diabetes, but the mechanisms remain unclear. Our study aimed to evaluate the effects of a diet rich in whole grains compared with a diet containing the same amount of refined grains on insulin sensitivity and markers of lipid peroxidation and inflammation. In a randomized crossover study, 22 women and 8 men (BMI 28 +/- 2) were given either whole-grain or refined-grain products (3 bread slices, 2 crisp bread slices, 1 portion muesli, and 1 portion pasta) to include in their habitual daily diet for two 6-wk periods. Peripheral insulin sensitivity was determined by euglycemic hyperinsulinemic clamp tests. 8-Iso-prostaglandin F(2alpha) (8-iso PGF(2alpha)), an F(2)-isoprostane, was measured in the urine as a marker of lipid peroxidation, and highly sensitive C-reactive protein and IL-6 were analyzed in plasma as markers of inflammation. Peripheral insulin sensitivity [mg glucose . kg body wt(-1) . min(-1) per unit plasma insulin (mU/L) x 100] did not improve when subjects consumed whole-grain products (6.8 +/- 3.0 at baseline and 6.5 +/- 2.7 after 6 wk) or refined products (6.4 +/- 2.9 and 6.9 +/- 3.2, respectively) and there were no differences between the 2 periods. Whole-grain consumption also did not affect 8-iso-PGF(2alpha) in urine, IL-6 and C-reactive protein in plasma, blood pressure, or serum lipid concentrations. In conclusion, substitution of whole grains (mainly based on milled wheat) for refined-grain products in the habitual daily diet of healthy moderately overweight adults for 6-wk did not affect insulin sensitivity or markers of lipid peroxidation and inflammation.
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