Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo
Judge MP, Harel O, Lammi-Keefe CJ
The American journal of clinical nutrition · 129 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Mental Health
- Gobierno
- NIMH NIH HHS
- Subvenciones
- National Institute of Mental Health (K01 MH087219)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2007-06-01 · Am J Clin Nutr · vol. 85 · número 6 · págs. 1572–1577
- Editorial
- Elsevier BV
- Citado
- 239 citas · más que el 99% de estudios similares · 12.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Child Nutrition and Water Access · Birth, Development, and Health
- Palabras clave
- docosahexaenoic acid, omega-3 fatty acids, maternal supplementation, pregnancy, functional foods, infant cognitive development, cereal bars
- MeSH
- humans, prenatal exposure delayed effects, docosahexaenoic acids, double-blind method, problem solving, pregnancy, pregnancy trimester, second, pregnancy trimester, third, dietary supplements, adolescent, adult, infant, female, male, recognition, psychology
3 autores
- Michelle Price Judge🇺🇸Pennington Biomedical Research Center; Louisiana State University; University of Connecticut
- Ofer Harel🇺🇸Pennington Biomedical Research Center; Louisiana State University; University of Connecticut
- Carol J. Lammi‐Keefe🇺🇸 · autor de correspondenciaPennington Biomedical Research Center; Louisiana State University; University of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There are few studies reporting on docosahexaenoic acid (DHA, 22:6n-3) supplementation during pregnancy and infant cognitive function. DHA supplementation in pregnancy and infant problem solving in the first year have not been investigated.
Objective
We tested the hypothesis that infants born to women who consumed a DHA-containing functional food during pregnancy would demonstrate better problem-solving abilities and recognition memory than would infants born to women who consumed the placebo during pregnancy.
Design
In a double-blind, placebo-controlled, randomized trial, pregnant women consumed a DHA-containing functional food or a placebo from gestation week 24 until delivery. Study groups received DHA-containing cereal-based bars (300 mg DHA/92-kcal bar; average consumption: 5 bars/wk; n = 14) or cereal-based placebo bars (n = 15). The Infant Planning Test and Fagan Test of Infant Intelligence were administered to infants at age 9 mo. The problem-solving trial included a support step and a search step. The procedure was scored on the basis of the infant's performance on each step and on the entire problem (intention score and total intentional solutions). Scores were generated on the basis of the cumulative performance of the infant on 5 trials.
Results
Treatment had significant effects on the performance of problem-solving tasks: total intention score (P = 0.017), total intentional solutions (P = 0.011), and number of intentional solutions on both cloth (P = 0.008) and cover (P = 0.004) steps. There were no significant differences between groups in any measure of Fagan Test of Infant Intelligence.
Conclusion
These data point to a benefit for problem solving but not for recognition memory at age 9 mo in infants of mothers who consumed a DHA-containing functional food during pregnancy.
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