Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP
The American journal of clinical nutrition · 887 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (AG14683-01A2)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2007-06-01 · Am J Clin Nutr · vol. 85 · número 6 · págs. 1586–1591
- Editorial
- Elsevier BV
- Citado
- 1,446 citas · más que el 100% de estudios similares · 87.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, calcium supplementation, cancer risk, postmenopausal women, 25-hydroxyvitamin D, fracture incidence, dietary supplements, rural women
- MeSH
- humans, neoplasms, calcium, calcifediol, vitamin d, incidence, logistic models, double-blind method, dietary supplements, middle aged, female, fractures, bone, kaplan-meier estimate
5 autores
- Joan M. Lappe🇺🇸 · autor de correspondenciaCreighton University
- Dianne Travers‐Gustafson🇺🇸Creighton University
- K. Michael Davies🇺🇸Creighton University
- Robert R. Recker🇺🇸Creighton University
- Robert P. Heaney🇺🇸Creighton University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking.
Objective
The purpose of this analysis was to determine the efficacy of calcium alone and calcium plus vitamin D in reducing incident cancer risk of all types.
Design
This was a 4-y, population-based, double-blind, randomized placebo-controlled trial. The primary outcome was fracture incidence, and the principal secondary outcome was cancer incidence. The subjects were 1179 community-dwelling women randomly selected from the population of healthy postmenopausal women aged >55 y in a 9-county rural area of Nebraska centered at latitude 41.4 degrees N. Subjects were randomly assigned to receive 1400-1500 mg supplemental calcium/d alone (Ca-only), supplemental calcium plus 1100 IU vitamin D3/d (Ca + D), or placebo.
Results
When analyzed by intention to treat, cancer incidence was lower in the Ca + D women than in the placebo control subjects (P < 0.03). With the use of logistic regression, the unadjusted relative risks (RR) of incident cancer in the Ca + D and Ca-only groups were 0.402 (P = 0.01) and 0.532 (P = 0.06), respectively. When analysis was confined to cancers diagnosed after the first 12 mo, RR for the Ca + D group fell to 0.232 (CI: 0.09, 0.60; P < 0.005) but did not change significantly for the Ca-only group. In multiple logistic regression models, both treatment and serum 25-hydroxyvitamin D concentrations were significant, independent predictors of cancer risk.
Conclusions
Improving calcium and vitamin D nutritional status substantially reduces all-cancer risk in postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00352170.
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