Improvement of insulin resistance after diet with a whole-grain based dietary product: results of a randomized, controlled cross-over study in obese subjects with elevated fasting blood glucose
Rave K, Roggen K, Dellweg S, Heise T, tom Dieck H
The British journal of nutrition · 74 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-06-12 · Br J Nutr · vol. 98 · número 5 · págs. 929–936
- Editorial
- Cambridge University Press
- Citado
- 116 citas · más que el 95% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Diabetes, Cardiovascular Risks, and Lipoproteins · Diabetes Treatment and Management · Diet, Metabolism, and Disease
- Palabras clave
- insulin resistance, meal replacement, obesity, type 2 diabetes prevention, weight loss, fasting insulin, serum lipids, HOMA-IR
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, obesity, body weight, insulin, blood glucose, risk factors, cross-over studies, nutritive value, dietary fiber, adolescent, adult, aged, middle aged, female, male, nutritional physiological phenomena, edible grain
5 autores
- Klaus Rave🇩🇪Profil Institute for Metabolic Research
- Kerstin Roggen🇩🇪 · autor de correspondenciaProfil Institute for Metabolic Research
- Sibylle Dellweg🇩🇪Profil Institute for Metabolic Research
- Tim Heise🇩🇪Profil Institute for Metabolic Research
- Heike tom Dieck
Resumen
El texto original del estudio, en el idioma en que se publicó.
Subjects with obesity and elevated fasting blood glucose are at high risk of developing type 2 diabetes which may be reduced by a dietary intervention leading to an improvement of insulin resistance. We investigated the potential of a whole-grain based dietary product (WG) with reduced starch content derived from double-fermented wheat during a hypo-energetic diet to positively influence body weight, fasting blood glucose, insulin resistance and lipids in comparison to a nutrient-dense meal replacement product (MR) in a randomized two-way cross-over study with two 4-week treatment periods separated by a 2-week wash-out. Subjects replaced at least two daily meals with WG and MR, respectively, targeting for a consumption of 200 g of either product per day. Total daily energy intake was limited to 7120 kJ. Thirty-one subjects (BMI 33.9 (SD 2.7) kg/m2, fasting blood glucose 6.3 (SD 0.8) mmol/l) completed the study. In both treatment groups body weight (-2.5 (SD 2.0) v. - 3.2 (SD 1.6) kg for WG v. MR), fasting blood glucose (-0.4 (SD 0.3) v. -0.5 (SD 0.5) mmol/l), total cholesterol (-0.5 (SD 0.5) v. -0.6 (SD 0.5) mmol/l), TAG (-0.3 (SD 0.9) v. -0.3 (SD 1.2) mmol/l) and homeostasis model assessment (HOMA) insulin resistance score (-0.7 (SD 0.8) v. -1.1 (SD 1.7) microU/ml x mmol/l) improved (P < 0.05) with no significant differences between the treatments. After statistical adjustment for the amount of body weight lost, however, the comparison between both groups revealed that fasting serum insulin (P = 0.031) and HOMA insulin resistance score (P = 0.049) improved better with WG than with MR. We conclude that WG favourably influences metabolic risk factors for type 2 diabetes independent from the amount of body weight lost during a hypo-energetic diet.
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