Magnesium supplementation and perinatal hypoxia: outcome of a parallel group randomised trial in pregnancy
Harrison V, Fawcus S, Jordaan E
BJOG : an international journal of obstetrics and gynaecology · 16 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-06-18 · BJOG · vol. 114 · número 8 · págs. 994–1002
- Editorial
- Wiley
- Citado
- 25 citas · más que el 81% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 12 trabajos
- Acceso
- De pago
- Áreas de investigación
- Neonatal and fetal brain pathology · Pregnancy and preeclampsia studies · Magnesium in Health and Disease
- Palabras clave
- magnesium supplementation, perinatal hypoxia, hypoxic-ischemic encephalopathy, pregnancy, fetal heart rate decelerations, stillbirth, Apgar score, Black women, low socioeconomic status, medication adherence
- MeSH
- fetal heart, humans, hypoxia-ischemia, brain, stearic acids, delayed-action preparations, apgar score, pregnancy outcome, pilot projects, double-blind method, pregnancy, dietary supplements, adolescent, adult, middle aged, infant, newborn, female, meconium aspiration syndrome, stillbirth, arrhythmias, cardiac
3 autores
- V. C. Harrison🇿🇦 · autor de correspondenciaSouth African Medical Research Council; University of Cape Town
- Sue Fawcus🇿🇦South African Medical Research Council; University of Cape Town
- Elizabeth Margaretha Jordaan🇿🇦South African Medical Research Council; University of Cape Town
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the effects of magnesium supplementation in pregnancy on the incidence of hypoxic-ischaemic encephalopathy (HIE).
Design
A randomised double-blind placebo-controlled study.
Setting
A Midwife Obstetric Unit and its two referral hospitals in Cape Town, South Africa.
Population
A group of 4494 black pregnant women of low socio-economic status.
Method
Mothers, from the time of booking until delivery, were randomised to receive two identical tablets daily, containing either 128 mg slow-release magnesium stearate or lactose sugar.
Main outcome measures
Primary: The incidence of HIE. Secondary: The incidence of fetal heart rate decelerations, term Stillbirths, Low Apgar Scores, Meconium Aspiration Pneumonia.
Results
The incidence of HIE (0.9%) was considerably less than anticipated (2%). There were 22 infants in the placebo group and 15 infants in the supplemented group (P = 0.279). The difference was not significant. Secondary outcomes such as late fetal heart rate decelerations (P = 0.002) and term stillbirths (P = 0.016) were reduced significantly in the supplemented group, but this finding needs further substantiation.
Conclusions
Magnesium supplementation did not reduce the incidence of HIE significantly, probably because the study was underpowered and compliance was relatively poor.
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