Effect of walnut-enriched restructured meat in the antioxidant status of overweight/obese senior subjects with at least one extra CHD-risk factor
Canales A, Benedí J, Nus M, Librelotto J, Sánchez-Montero JM, Sánchez-Muniz FJ
Journal of the American College of Nutrition · 43 citas
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Alimentación controladaFinanciación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-06-01 · J Am Coll Nutr · vol. 26 · número 3 · págs. 225–232
- Editorial
- Taylor & Francis
- Citado
- 71 citas · más que el 92% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Meat and Animal Product Quality
- Palabras clave
- restructured meat, antioxidant status, coronary heart disease risk, overweight and obesity, older adults, erythrocyte catalase, superoxide dismutase, glutathione, lipid peroxidation, serum uric acid, paraoxonase 1, smoking, hypercholesterolemia, functional foods, oxidative stress
- MeSH
- humans, juglans, cardiovascular diseases, obesity, aryldialkylphosphatase, glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, lipids, glutathione, antioxidants, risk factors, cross-over studies, sex factors, oxidation-reduction, oxidative stress, meat products, middle aged, female, male, overweight
6 autores
- Amaia Canales🇪🇸Universidad Complutense de Madrid
- Juana Benedı́🇪🇸Universidad Complutense de Madrid
- Meritxell Nus🇪🇸Universidad Complutense de Madrid
- Josana Librelotto🇪🇸Universidad Complutense de Madrid
- J.M. Sánchez-Montero🇪🇸Universidad Complutense de Madrid
- Francisco José Sánchez-Muniz🇪🇸 · autor de correspondenciaUniversidad Complutense de Madrid
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A number of recent studies indicate that antioxidants reduce the oxidative stress associated with the development of coronary heart diseases (CHD).
Objective
(i) To investigate whether the erythrocyte catalase (CAT), superoxide dismutase (SOD), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), and lipid peroxidation (LPO), and serum uric acid and paraoxonase-1 (PON1) are modified at increased CHD-risk individuals consuming walnut-enriched meat (WM), (ii) to evaluate whether these changes were influenced by basal serum cholesterol, body mass index or smoking habit.
Design
The study was a non blinded, cross-over, placebo-controlled trial in which 22 volunteers (60% overweight and 40% obese) with increased CHD-risk were randomly assigned to receive WM or control meat (CM) during two different periods of 5 weeks.
Results
A significant interaction time*treatment (p < 0.05) was observed in all enzymes and substrates tested except HDL-C, uric acid and LPO. The treatment significantly increased CAT activity, total glutathione and GSSG (p < 0.05). Significant gender*time*treatment interaction (p = 0.043) for total glutathione was found increasing at the end of the WM period in male but not changing in female. Total glutathione and GSH/GSSG ratio (p < 0.05) were lower in smokers. Hypercholesterolemics presented higher uric acid (p < 0.05) but no enzyme activities or substrate concentrations were different from those of normocholesterolemics.
Conclusions
The WM tested appears to be a functional food as it improved the antioxidant status of increased CHD-risk volunteers. Despite its high energy content, it also appears adequate for overweight and obese people because did not exert negative effect upon body weight.
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