Effects of dietary nitrate on oxygen cost during exercise
Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B
Acta physiologica (Oxford, England) · 438 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-07-17 · Acta Physiol (Oxf) · vol. 191 · número 1 · págs. 59–66
- Editorial
- Wiley
- Citado
- 636 citas · más que el 100% de estudios similares · 42.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Palabras clave
- dietary nitrate, oxygen consumption, exercise efficiency, nitric oxide, nitrite, nitrate reduction, submaximal exercise, lactate, energy metabolism
- MeSH
- humans, sodium chloride, nitrates, oxygen, exercise test, exercise, diet, analysis of variance, cross-over studies, oxygen consumption, physical endurance, exercise tolerance, dietary supplements, adult, male
4 autores
- Filip Jon Larsen🇸🇪Karolinska Institutet; Swedish School of Sport and Health Sciences
- Eddie Weitzberg🇸🇪Karolinska Institutet
- Jon O. Lundberg🇸🇪Karolinska Institutet
- Bjorn T. Ekblom🇸🇪 · autor de correspondenciaKarolinska Institutet; Swedish School of Sport and Health Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
Nitric oxide (NO), synthesized from l-arginine by NO synthases, plays a role in adaptation to physical exercise by modulating blood flow, muscular contraction and glucose uptake and in the control of cellular respiration. Recent studies show that NO can be formed in vivo also from the reduction of inorganic nitrate (NO(3) (-)) and nitrite (NO(2) (-)). The diet constitutes a major source of nitrate, and vegetables are particularly rich in this anion. The aim of this study was to investigate if dietary nitrate had any effect on metabolic and circulatory parameters during exercise.
Method
In a randomized double-blind placebo-controlled crossover study, we tested the effect of dietary nitrate on physiological and metabolic parameters during exercise. Nine healthy young well-trained men performed submaximal and maximal work tests on a cycle ergometer after two separate 3-day periods of dietary supplementation with sodium nitrate (0.1 mmol kg(-1) day-1) or an equal amount of sodium chloride (placebo).
Results
The oxygen cost at submaximal exercise was reduced after nitrate supplementation compared with placebo. On an average Vo(2) decreased from 2.98 +/- 0.57 during CON to 2.82 +/- 0.58 L min(-1) during NIT (P < 0.02) over the four lowest submaximal work rates. Gross efficiency increased from 19.7 +/- 1.6 during CON to 21.1 +/- 1.3% during NIT (P < 0.01) over the four lowest work rates. There was no difference in heart rate, lactate [Hla], ventilation (VE), VE/Vo(2) or respiratory exchange ratio between nitrate and placebo during any of the submaximal work rates.
Conclusion
We conclude that dietary nitrate supplementation, in an amount achievable through a diet rich in vegetables, results in a lower oxygen demand during submaximal work. This highly surprising effect occurred without an accompanying increase in lactate concentration, indicating that the energy production had become more efficient. The mechanism of action needs to be clarified but a likely first step is the in vivo reduction of dietary nitrate into bioactive nitrogen oxides including nitrite and NO.
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