Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study
Oelkers-Ax R, Leins A, Parzer P, Hillecke T, Bolay HV, Fischer J, Bender S, Hermanns U, Resch F
European journal of pain (London, England) · 48 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universität Heidelberg
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-08-01 · Eur J Pain · vol. 12 · número 3 · págs. 301–313
- Editorial
- Wiley
- Citado
- 96 citas · más que el 87% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- De pago
- Áreas de investigación
- Migraine and Headache Studies · Pediatric Pain Management Techniques · Temporomandibular Joint Disorders
- Palabras clave
- music therapy, pediatric migraine, migraine prophylaxis, headache frequency, non-pharmacological treatment, school-aged children, headache education
- MeSH
- humans, petasites, plant roots, anti-inflammatory agents, non-steroidal, plant extracts, combined modality therapy, phytotherapy, music therapy, follow-up studies, prospective studies, double-blind method, patient compliance, family, mental disorders, child, female, male, migraine disorders, patient education as topic, relaxation therapy, imagery, psychotherapy
9 autores
- Rieke Oelkers‐Ax🇩🇪 · autor de correspondenciaHeidelberg University
- Anne Kathrin Leins🇩🇪Deutsches Zentrum für Musiktherapieforschung
- Peter Parzer🇩🇪Heidelberg University
- Thomas Karl Hillecke🇩🇪SRH University of Applied Sciences Heidelberg
- Hans Volker Bolay🇩🇪SRH University of Applied Sciences Heidelberg
- Jochen Fischer🇩🇪Heidelberg University
- Stephan Bender🇩🇪Heidelberg University
- Uta Hermanns🇩🇪Heidelberg University
- Franz Resch🇩🇪Heidelberg University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Migraine is very common in school-aged children, but despite a number of pharmacological and non-pharmacological options for prophylaxis, randomized controlled evidence in children is small. Evidence-based prophylactic drugs may have considerable side effects.
Objective
This study was to assess efficacy of a butterbur root extract (Petadolex) and music therapy in primary school children with migraine.
Design
Prospective, randomized, partly double-blind, placebo-controlled, parallel-group trial.
Methods
Following a 8-week baseline patients were randomized and received either butterbur root extract (n=19), music therapy (n=20) or placebo (n=19) over 12 weeks. All participants received additionally headache education ("treatment as usual") from the baseline onwards. Reduction of headache frequency after treatment (8-week post-treatment) as well as 6 months later (8-week follow-up) was the efficacy variable.
Results
Data analysis of subjects completing the respective study phase showed that during post-treatment, only music therapy was superior to placebo (p=0.005), whereas in the follow-up period both music therapy and butterbur root extract were superior to placebo (p=0.018 and p=0.044, respectively). All groups showed a substantial reduction of attack frequency already during baseline.
Conclusion
Butterbur root extract and music therapy might be superior to placebo and may represent promising treatment approaches in the prophylaxis of paediatric migraine.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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